Mayo Foundation for Medical Education and Research

US Government As Represented by the Secretary of the Army

William A Carey

David R Holmes, Iii

Moses Rodriguez

Barry K Gilbert

Clifton R Haider

Arthur E Warrington

Robert W Techentin

Michael J Joyner

Christopher L Felton

Timothy B Curry

Jens O Watzlawik

Charlotte Sue Van Dorn

Victor A Convertino

In accordance with some embodiments, systems, methods, and media for estimating compensatory reserve and predicting hemodynamic decompensation using physiological data are provided. In some embodiments, a system for estimating compensatory reserve is provided, the system comprising: a processor programmed to: receive a blood pressure waveform of a subject; generate a first sample of the blood pressure waveform with a first duration; provide the sample as input to a trained CNN that was trained using samples of the first duration from blood pressure waveforms recorded from subjects while decreasing the subject's central blood volume, each sample being associated with a compensatory reserve metric; receive, from the trained CNN, a first compensatory reserve metric based on the first sample; and cause information indicative of remaining compensatory reserve to be presented.

Systems, methods and media for estimating compensatory reserve and predicting hemodynamic decompensation using physiological data

The invention provides methods for the treatment of neonatal hypoxia and associated white matter disease or injury, particularly in infant, including neonatal, animals, particularly Periventricular Leukomalacia (PVL) comprising administering one or more CNS reactive antibody, particularly selected from IgM12, IgM22, IgM42 and IgM46. Compositions for use in treatment of white matter disease or injury in infants, particularly PVL are provided. The invention provides methods for alleviation of neuromotor or neurodevelopmental deficits associated with neonatal hypoxia and associated with white matter injury, including PVL, in an infant.

Treatment of neonatal hypoxia including impairments or effects thereof

Growing community of inventors

Rochester, MN, United States of America

William A Carey