Hoechst Aktiengesellschaft

Willi Stammberger

Werner Fulberth

Richard Leeb

Manfred Radau

Irmgard Hoffmann

Karl Schmitt

Alfred Sickmuller

Werner Fulbreth

Stabilized medicinal substances, a process for the preparation thereof, and stable medicinal formulations Stabilized compounds of the formula I ##STR1## in which R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the stated meanings, and a process for the preparation thereof, are described. The stabilized compounds are suitable for the manufacture of medicinal formulations. The formula I compounds are stabilized by a polymeric protective coating before being compressed in tablet form.

Stabilized polymer film coated compounds and stabilized formulations in

Stabilized compounds of the formula I ##STR1## in which R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the stated meanings, and a process for the preparation thereof, are described. The stabilized compounds are suitable for the manufacture of medicinal formulations.

Stabilized medicinal substances, a process for the preparation thereof,

Composition containing acesulfam or a salt thereof, a soluble, CO.sub.2 -yielding compound, optionally a physiologically acceptable acid as auxiliary, and gelatin powder as dry binder, and its use for the manufacture of tablets.

Acesulfam-containing composition tablets on the basis thereof and

What is disclosed are medicinal compositions, useful as anti-depressive agents, containing a compound of the formula; ##STR1## in which R.sub.1, R.sub.3 and R.sub.4, which may be identical or different, and represent hydrogen atoms or lower alkyl or aralkyl groups, and R.sub.2 and R.sub.2 ', which may be identical or different, represent hydrogen or halogen atoms, hydroxy or trifluoromethyl groups or lower alkyl, alkoxy or aralkoxy groups, it also being possible that two adjacent radicals form an alkylene-dioxy radical, and R.sub.5 represents a hydrogen or halogen atom, a hydroxy, trifluoromethyl or nitro group or a lower alkyl, alkoxy or aralkoxy radical, and their salts with acids (active substance A) together with 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4 (3H,5H)-dione (active substance B), and their use as antidepressive agent.

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Hofheim am Taunus, Germany

Willi Stammberger