National Jewish Health

National Jewish Medical and Research Center

Willi K Born

Erwin W Gelfand

Arihiko Kanehiro

Michael F Lahn

Disclosed is a method to reduce airway hyperresponsivesness in an animal by the direct delivery to the lungs of aerosolized antibodies against T cell receptors. The method is particularly useful for treating airway hyperresponsiveness associated with allergic inflammation, is effective at extremely low doses of antibody, and does not have a substantial effect on the peripheral immune system.

Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies

Disclosed is a method for regulation of airway hyperresponsiveness by modulating the action of &#x3b3;&#x3b4; T cells in a patient. Also disclosed are methods for identifying compounds that regulate airway hyperresponsiveness by modulating &#x3b3;&#x3b4; T cell action.

Modulation of gamma delta T cells to regulate airway hyperresponsiveness

Disclosed is a method for regulation of airway hyperresponsiveness by modulating the action of &ggr;&dgr; T cells in a patient. Also disclosed are methods for identifying compounds hyperresponsiveness by modulating &ggr;&dgr; T cell action.

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Denver, CO, United States of America

Willi K Born