Dr. Karl Thomae Gmbh

Boehringer Ingelheim Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Karl Thomae Gmbh

Celamerck Gmbh & Co. Kg

Boehringer Ingelheim Gesellschaft MIT Beschrankter Haftung

Willi Diederen

Joachim Heider

Volkhard Austel

Norbert Hauel

Manfred Reiffen

Wolfgang Eberlein

Walter Kobinger

Eberhard Kutter

Jacobus C Van Meel

Christian Lillie

Klaus Reinhold Noll

Andreas Bomhard

Berthold Narr

Jacques Van Meel

Rudolf Kadatz

Manfred Psiorz

Walter Haarmann

Jurgen Dammgen

Walter Haarman

Josef Nickl

Erich Muller

Michael Entzeroth

Rainer Zimmermann

Jochen Schmid

Willy Roth

Annerose Mauz

Robin G Shanks

Axel Prox

Albert Reuter

The invention relates to new 2-hydroxy-n-propylamines of the formula

2-hydroxypropylamino-alkyl-benzimidazoly-5-yl derivatives and their use

The present invention relates to new heteroaromatic amine derivatives of general formula ##STR1## wherein the substituents are defined hereinbelow, which have valuable pharmacological properties, particularly a heart rate lowering activity and a positive inotropic activity.

Heteroaromatic amine derivatives

Heteroaromatic amine derivatives, pharmaceutical compositions containing

The invention relates to new imidazo-benzoxazinones of formula ##STR1## wherein the substituents are defined herein below, which compounds are useful in the treatment of cardiovascular disorders.

Imidazo-benzoxazinones, the preparation thereof and pharmaceutical

Compounds of the formula ##STR1## wherein A, B, C and D are --N.dbd., HN.dbd., R.sub.3 N.dbd., O.dbd.C.dbd., HC.tbd., HO--C.tbd. or R.sub.3 SO.sub.2 --O--C.tbd.; and

2-phenyl-imidazopyridin-ones and also useful as cardiotonics and

Compounds of the formula ##STR1## wherein A, B, C and D are each independently --N.dbd. or --CH.dbd., provided, however, that at least two of them must be --N.dbd., and when A and C are both --N.dbd., at least one or both of B and D must be --N.dbd.; and

2-phenyl-imidazo-pyrazines, -pyridazines and -triazines

The invention relates to novel 2-phenyl-imidazoles of the formula ##STR1## and the tautomers and acid addition salts thereof, particularly the pharmacologically acceptable acid addition salts, which exhibit valuable pharmacological properties, particularly an effect on the contractility of the heart muscle. The compounds of Formula I may be prepared by methods conventionally used for similar compounds.

Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same

The invention relates to new imidazo derivatives of the formula ##STR1## wherein 'A-D and R.sup.1 -R.sup.3 are as defined in the specification'. The new compounds have valuable pharmacological properties, particularly antithrombotic and cardiovascular properties such as a cardiotonic activity and/or an effect on blood pressure, and can be prepared using methods known per se.

Imidazo[1,2a]pyridines and their use as cardiotonic agents

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; monosubstituted alkyl of 1 to 3 carbon atoms, where the substituent is pyridyl, methypyridyl, phenyl, mono-, di- or trisubstituted phenyl, where the substituents on the phenyl ring, which may be identical to or different from each other, are selected from the group consisting of one amino, one dimethylamino, one to two hydroxyls, one to three methoxys and one to three halogens; .omega.-monosubstituted alkyl of 2 to 4 carbon atoms, where the substituent is hydroxyl or di(alkyl of 1 to 3 carbon atoms)amino; phenyl; monohalo-phenyl; unsubstituted or monosubstituted straight or branched alkanoyl of 1 to 6 carbon atoms, where the substituent is phenyl, methoxyphenyl or cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or monosubstituted phenylsulfonyl, where the substituent is methyl or methoxy; and

Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones

There are disclosed novel imidazole derivatives of the formula. ##STR1## and derivatives of the formula ##STR2## the tautomers thereof, and non-toxic, pharmacologically acceptable addition salts thereof with inorganic or organic acids. The compounds described herein are useful in treating cardiac insufficiency.

Imidazole derivatives and pharmaceutical compositions containing them

Imidazo[4,5-c]pyridazine-3-ones, imidazo[4,5-d]pyridazine-4-ones,

2-phenyl-imidazo-pyrazines, useful as cardiotonics

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; monosubstituted alkyl of 1 to 3 carbon atoms, where the substituent is pyridyl, methylpyridyl, phenyl, mono-, di- or trisubstituted phenyl, where the substituents on the phenyl ring, which may be identical to or different from each other, are selected from the group consisting of one amino, one dimethylamino, one to two hydroxyls, one to three methoxys and one to three halogens; .omega.-monosubstituted alkyl of 2 to 4 carbon atoms, where the substituent is hydroxyl or di(alkyl of 1 to 3 carbon atoms)amino; phenyl; monohalo-phenyl; unsubstituted or monosubstituted straight or branched alkanoyl of 1 to 6 carbon atoms, where the substituent is phenyl, methoxyphenyl or cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or monosubstituted phenylsulfonyl, where the substituent is methyl or methoxy; and,

There are disclosed novel imidazole derivatives of the formula ##STR1## and derivatives of the formula ##STR2## the tautomers thereof, and non-toxic, pharmacologically acceptable addition salts thereof with inorganic or organic acids. The compounds described herein are useful in treating cardiac insufficiency.

Imidazo[4,5-b] and [4,5-c]pyridine derivatives having cardiotonic

Compounds of the formula ##STR1## wherein one of A and B is methenyl (--CH.dbd.) and the other is carbonyl; R.sub.1 is (alkyl of 1 to 3 carbon atoms)mercapto, (alkyl of 1 to 3 carbon atoms)sulfinyl or (alkyl of 1 to 3 carbon atoms)sulfonyl; and

2-Phenyl-imidazo[4,5-c]pyridinones useful as cardiotonic agents

Growing community of inventors

Biberach, Germany

Willi Diederen