Lts Lohmann Therapie-systeme Ag

Ucb Pharma Gmbh

Ucb Biopharma Sprl

Willi Cawello

Hans-Michael Wolff

Walter Müller

Marco Emgenbroich

Johannes Josef Leonhard

Kristina Kassner

Aurélia Lappert

Martin Alexander Schubert

Walter Muller

Aurelia Lappert

The present invention relates to a transdermal therapeutic system, comprising (a) a backing layer, (b) a solvent-based self-adhesive matrix layer containing rotigotine as active ingredient, and (c) a release liner, wherein the self-adhesive matrix layer has a coating weight of about 75-400 g/mand comprises a reservoir layer containing about 9-25 wt.-% rotigotine based on the weight of the reservoir layer, a kit comprising two transdermal therapeutic systems of the present invention as well as a method for the preparation of the transdermal therapeutic system of the present invention. In addition, the present invention relates to a transdermal therapeutic system comprising rotigotine as active ingredient for use in the treatment of patients suffering from Parkinson's disease, Parkinson's plus syndrome, depression, fibromyalgia and the restless-legs syndrome and for use in the treatment or prevention of dopaminergic neuron loss or cognitive disorders by transdermal administration of rotigotine once or twice weekly, wherein the transdermal therapeutic system comprises a backing layer, a solvent-based rotigotine containing self-adhesive matrix layer as well as a release liner and is adapted to allow for the transdermal administration of therapeutically effective amounts of rotigotine for at least 3 days.

Multi-day patch for the transdermal administration of rotigotine

A modified release formulation of lacosamide suitable for once-daily administration.

Daily formulation of lacosamide

Growing community of inventors

Monheim, Germany

Willi Cawello