Bio-Quant, Inc.

University of Michigan

Willfried Schramm

A device and process for detecting the presence of organic molecular analytes in a fluid comprising a first binding component having a predetermined first affinity for specifically reversibly binding an analyte, a molecular conjugate of the analyte with a signal generating molecule that generates a detectable signal, and a second binding component having a predetermined second affinity for reversibly binding the signal generating molecule. In the presence of analyte, a fluid conducting system allows competitive binding of the analyte with the molecular conjugate and causes displacement of the conjugate and conducts the displaced conjugate to the second binding component. The signal generating molecule generates a detectable signal distinguishing binding thereof at the first or second binding components thereby indicating the presence of the analyte in the fluid.

Immunoassay device for continuous monitoring

A diagnostic device (10) includes a plurality of standard solutions for being dispensed into a row of wells (20), the standard solutions contained within a predetermined number of standard tubes which are spaced a predetermined distance apart equal to the distance between the plurality of wells (20) whereby a single pipettor (28) can transfer the standards from the entire row of standard tubes (26) to a single row of wells (20) in a single transfer step. The invention further provides a mixing mechanism for agitating the entirety of a microtiter plate seated thereover.

Diagnostic device

The present invention is an oral fluid collection article for placement in the buccal cavity of an individual for the collection and fittering of a saliva fluid. The collection article has a semi-permable membrane container enclosing an osmotic substance means.

Growing community of inventors

Ann Arbor, MI, United States of America

Willfried Schramm