Universidad De Sevilla

Universiteit Twente

Tide Microfluidics B.v.

Solstice Pharmaceuticals B.v.

Willem Van Hoeve

Roel Penterman

Detlef Lohse

Richard Petrus Hogervorst

Elena De Castro Hernàndez

José Manuel Gordillo Arias De Saavedra

Andreas Michael Versluis

The present invention is related to a system and method for controlled manufacturing of mono-disperse microbubbles. According to the invention, the mono-disperse nature of the collection of generated microbubbles can be improved by releasing the pressurized gaseous medium used in the system using release valve units. This further allows the system to be embodied as a portable system. In turn, the operator of an ultrasound imaging apparatus may use the system according to the invention to generate microbubbles on a patient-by-patient basis.

System and method for controlled manufacturing of mono-disperse microbubbles

An apparatus for mass producing monodisperse microbubbles contains a microfluidic flow focusing device. The microfluidic flow focusing device includes a dispersed phase fluid supply channel having an outlet that discharges into a flow focusing junction, a continuous phase fluid supply channel having an outlet that discharges into the flow focusing junction, and a bubble formation channel having an inlet disposed at the flow focusing junction. The configuration of the flow focusing junction is such that, in operation, a flow of dispersed phase fluid discharging from the outlet of the dispersed phase fluid supply channel is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel.

Apparatus and method for mass producing a monodisperse microbubble agent

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Enschede, Netherlands

Willem Van Hoeve