European Community (ec)

Willem Janssens

Christos Apostolidis

Lothar Koch

Jacques Van Geel

Roger Molinet

Hermann Schweickert

Michel Ougier

John McGinley

Bruno Brandalise

Josef M&ouml;llenbeck

This invention relates to a method and an apparatus for preparing Bi-213 to be integrated in a radioimmunocojugate for human therapeutic use. According to the invention the method comprises the sequence of steps as follows: a) an ampoule containing colloid-free actinium-225, obtained from drying an actinium nitrate solution, is loaded into a container provided with radiation panels ; b) a dissolving medium is poured into the ampoule ; c) the solution obtained in the ampoule is transferred into an ion exchange column ; d) an elution medium is circulated through the column ; e) the eluate containing eluted Bi-213 is pumped towards a vial for quantification and quality control.

Method and apparatus for preparing Bi-213 for human therapeutic use

This invention refers to a method for producing Actinium-225, comprising the steps of preparing a target (,) containing Radium-226, of irradiating this target with protons in a cyclotron and of chemically separating Actinium from the irradiated target material thereafter. According to the invention the proton energy in the cyclotron is adjusted such that the energy incident on the Ra-226 is between 10 and 20 MeV, preferably between 9 14 and 17 MeV. By this means the yield of production of the desired isotope Ac-225 is enhanced with respect to other radioisotopes.

Method for producing Ac-225 by irradiation of Ra-226 with protons

Growing community of inventors

Forst, Germany

Willem Janssens