Gist-brocades N.v.

Roussel Uclaf

Akzo N.v.

Dsm N.v.

Van Zoest, Willem J.

Smid, Peter M.

Weber, Pieter G.

Marx, Arthur F.

Willem J Van Zoest

Arthur F Marx

Jacobus Stark

Hong Sheng Tan

Jagdish C Kapur

Ferdinand Theodorus Van Rijn

Nicolaas Cornelis Barendse

Jacobus N Batist

Pieter Gijsbert Weber

Peter M Smid

The present invention provides a method of preparing an improved antifungal composition containing an antifungal compound of the polyene type such as natamycin wherein the antifungal compound is incorporated into the composition in a form which shows an enhanced activity, e.g. in the form of a solution and/or being in a modified polymorphic form.

Antifungal composition

New 9-alpha-hydroxy steroids are prepared by the introduction of substituents on the D-ring of 9-alpha-hydroxy-androst-4-ene-3,17-dione. The resulting compounds are useful intermediates in the synthesis of corticosteroids.

9-alpha-hydroxy steroids, process for their preparation, process for the

A process for the preparation of novel 14.alpha., 17.alpha.-dihydroxy-17.beta.-substituted steroids by reacting 14.alpha.-hydroxy-17-oxo-steroids with metal organic compounds and the use of the said novel steroids in the production of 14.alpha., 17.alpha.-methylenedioxy-pregnane derivatives.

14.alpha.,17.alpha.-dihydroxy-17.beta.-substituted steroids

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Schiedam, Netherlands

Willem J Van Zoest