Zeneca Limited

Cropdesign N.v.

Michigan State University

Cargill Inc.

Syngenta Corporation

Imperial Chemical Industries Limited

Katholieke Universiteit Leuven

Basf Plant Science Gmbh

Puratos Nv

Coave Therapeutics

Fugeia Nv

Croodesign, N.v.

Zeneca Agrochemicals

Willem F Broekaert

Sarah Bronwen Rees

Jozef Vanderleyden

Bruno Philippe Cammue

Rupert W Osborn

Frederik Leyns

Pierre Lejeune

Jan Delcour

Willy Dillen

Nam-Hai Chua

Natasha V Raikhel

Christophe Courtin

Anil Kush

Yves Hatzfeld

Genoveva Wivina De Samblanx

Miguel De Bolle

Franky Rg Terras

Valerie Frankard

Vladimir Mironov

John Anthony Ray

Ravindra Haribhai Tailor

Frederik Dhont

Bruno Pa Cammue

Ana Isabel Sanz Molinero

Christophe Reuzeau

Dirk Inze

Filip Arnaut

Wouter Cornelis Puijk

Lieven De Veylder

Robbert Hans Meloen

Tom Beeckman

Jacques Georis

Franky Fant

Ingrid Van Haesendonck

Aart Van Amerongen

Frans Borremans

Lolke Sijtsma

Wilhelmus Martinus Maria Schaaper

Wim Veraverbeke

Wilhelmus Martinus Josef Van Gelder

Bruno Philippe Angelo Cammue

Bruno P A Cammue

Franky R G Terras

Sheila Attenborough

Bruno Phillippe Cammue

Bram Damen

Shelia Attenborough

Philippe Moullier

Anna Depicker

Franky Terras

Sylvie De Buck

Chris De Wilde

Zhongyi Zhou

The present invention relates to modified adeno-associated virus (AAV) vectors for use in transducing a cell in the central nervous system (CNS) of a subject, and for use in the prevention or treatment of a CNS disease. In particular, the modified AAV vectors according to the present invention comprise at least one surface-bound saccharide, and are to be administered directly to the CNS but not intracerebroventricularly.

Modified adeno-associated virus vectors and delivery thereof into the central nervous system

The present invention provides a method for the extraction and isolation of soluble arabinoxylan products from cereal grain. Preferably, such soluble arabinoxylan product is any one of soluble arabinoxylan, arabinoxylan-oligosaccharides, xylose, arabinose, ferulic acid and mixtures thereof. Said method comprises partial debranning of whole cereal grains to obtain partially debranned cereal grains followed by roller milling of said partially debranned cereal grains to obtain cereal bran. The method further comprises the mashing of at least part of said cereal bran in water optionally involving the treatment of the mash with any one of an enzyme preparation, an acid, a base, a peroxide or combinations thereof, either simultaneously or sequentially, to solubilize and optionally depolymerize a fraction of the arabinoxylan comprised in said cereal bran. Preferably, said treatment is done with an enzyme preparation containing an endoxylanase. The method further comprises the separation from said mash of a solubilized fraction, which comprises at least part of the solubilized soluble arabinoxylan products.

Method for making pentoses and pentose-based soluble oligo/polysaccharides from cereal grain involving debranning technology

A method is provided for evaluating plant roots, comprising (i) growing a plant in a substantially transparent container charged with a particulate, non-transparent growing medium; and (ii) evaluating plant roots through the transparent container by digital imaging. An apparatus for evaluating plant roots in a high throughput manner is also provided.

Root evaluation

A method for increasing in a baked product, after baking, the level of water-soluble arabinoxylan with an average degree of polymerization ranging from 5 to 50, comprising preparing a dough for a baked product with flour having a total arabinoxylan content of at least 2.0%, and adding to the dough an enzyme preparation comprising at least one thermophilic endoxylanase in an amount at least two-fold higher than the amount conferring 90% of the maximal bread volume increase obtained by addition of such enzyme preparation to the recipe of the baked product. Using this method, baked products can be obtained that have a level of arabinoxylan of at least 1.7% The present invention further relates to baked products obtainable by this method, and to an improver and a dough which may be used for the preparation of such products.

Bread with increased arabinoxylo-oligosaccharide content

The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a Yield Enhancing Protein (YEP). The YEP is selected from a Vacuolar Processing Enzyme (VPE) or a CCA1-like polypeptide or a SAP-like polypeptide or a Seed Yield Promoting Factor 1 (SYPF1) polypeptide or a Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) activase (RCA) polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding such a YEP, which plants have enhanced yield-related traits relative to control plants. The invention also provides hitherto unknown YEP-encoding nucleic acids, and constructs comprising the same, useful in performing the methods of the invention.

Plants having enhanced yield-related traits and a method for making the same

The present invention relates to the use of oligosaccharides derived from arabinoxylan for use in the prevention and treatment of gastrointestinal infection. More particularly the invention provides a method for preventing or reducing the gastrointestinal infection of a animal or human being with bacteria associated with gastroenteritis through the supplementation of their diets with the said oligosaccharides.

Arabinoxylo-oligosaccharides useful against gastrointestinal infections

The present invention relates to preparations comprising (arabino)xylan oligosaccharides with average degree of polymerisation between 4 and 10 and average degree of arabinose substitution between 0.15 and 0.35, which beneficially modulate the intestinal flora, such preparation comprising both xylo- and arabinoxylo-oligosaccharides. Preferably, the arabinoxylooligosaccharides are substituted in part by hydroxycinnamic acids and exert antioxidant effects. Furthermore, it is preferred that the preparations according to the present invention have a nitrogen content below 0.16% (w/w) in order to ensure good organoleptic and color properties, particularly upon heating said preparations. In addition, food, beverage and nutritional supplement products comprising the preparations are provided as well as methods to prepare the said preparations.

(Arabino)xylan oligosaccharide preparation

The invention provides several promoters isolated from, which promoters are capable of driving and/or regulating the expression of an operably linked nucleic acid in a plant. The expression patterns of the promoters according to the invention have been studied inand some of the promoters displayed specific activity in particular cells, tissues or organs of the plant, while others displayed constitutive expression throughout substantially the whole plant. Some promoters showed weak expression, while others were strongly active.

Rice promoters

The present invention provides nutritional compositions, more particularly food supplements and processed food products, enriched with arabinoxylan-oligosaccharides and further comprising either or both water-unextractable arabinoxylans or water-soluble arabinoxylans. Preferably said nutritional compositions comprises both arabinoxylan-oligosaccharides and water-unextractable arabinoxylans.

Nutriment containing arabinoxylan and oligosaccharides

Array of transport elements for supporting and moving plant pots

A method is provided comprising (i) growing a plant in a substantially transparent container charged with a particulate, non-transparent growing medium; and (ii) evaluating plant roots through said transparent container by digital imaging. An apparatus for evaluating plant roots in a high throughput manner is also provided.

A process for breeding plants which comprises growing plants of a species in an array of containers charged with growing medium of uniform characteristics in an environment of controlled climatic conditions with controlled supply of nutrients and feed water and changing the positions of the containers within the environment as required to ensure at least substantially uniform exposure of all plants in the containers to conditions in the environment. A process for the breeding of open pollinating plants in a greenhouse environment is also provided. A process for breeding plants which comprises identifying trait leads.

Breeding plants

The present invention provides a method for producing preparations comprising soluble arabinoxylans as co-products of ethanol production through fermentation of whole-grain cereals. The method results in preparations that are highly enriched in soluble arabinoxylans, which can be used as a food, beverage, or feed ingredients.

Method for making soluble arabinoxylans as co-product of fermentation of whole-grain cereals

Growing community of inventors

Dilbeek, Belgium

Willem F Broekaert