Crucell Holland B.v.

Janssen Vaccines & Prevention B.v.

Willem Egbert Marissen

Robert Arjen Kramer

Cornelis Adriaan De Kruif

Alexander Berthold Hendrik Bakker

Alexander B H Bakker

Cornelius A De Kruif

Alexander Berthold Bakker

Provided are binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. Further provided are nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. In certain embodiments, they can be used in the post-exposure prophylaxis of rabies.

Binding molecules capable of neutralizing rabies virus and uses thereof

The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. Preferably, they can be used in the post-exposure prophylaxis of rabies.

The present invention provides pharmaceutical antibody formulations, in particular liquid pharmaceutical formulations comprising anti-rabies virus antibodies. The formulations can be used in the post exposure prophylaxis of rabies.

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Woerden, Netherlands

Willem Egbert Marissen