Akzo Nobel N.v.

Wilhelmina Maria Bagchus

Ralf Plate

The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R is H or together with R forms a &bgr;-epoxide or R is absent if there is a 5-10 or 4-5 double bond; R is (C -C ) alkyl or CF ; R is &bgr;H, &bgr;CH or together with R forms a &bgr;-epoxide or R is absent if there is a 5-10 double bond; R is H, lower alkyl; Y is &lsqb;H, H&rsqb;, &lsqb;OH, H&rsqb;, &boxH;O, &lsqb;OH, lower alkyl&rsqb;, &lsqb;OH, (C2-C5)alkenyl&rsqb;, &lsqb;OH, (C -C )alkynyl&rsqb; or (C -C ) alkylidene, whereby said alkyl, alkenyl, alkynyl and alkylidene is optionally halogenated; &boxH;NOR , whereby R is H, lower alkyl; dotted lines represent an optional double bond, or prodrugs thereof for the treatment of arthritic diseases and/or autoimmune diseases.

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Arnhem, Netherlands

Wilhelmina Maria Bagchus