Lonza Inc.

Lonza Ag

Astrazeneca Ab

Josef Stoffel

Renzo Bergamin

Wilhelm Quittmann

Lonza Guangzhou Research & Development Center Ltd

Dominique Roberge

Markus Eyholzer

Fabio Rainone

John McGarrity

Paul Hanselmann

Bertin Zimmermann

Stephan Elzner

Ellen Klegraf

Michael Gottsponer

Rongmin Chen

Wei Zhu

Feng Ye

Rhony Niklaus Aufdenblatten

Renzo Bergmin

Peter Ruppen

Leo Zumoberhaus

Daniel Friedrich Fischer

Thomas Peter Belser

Stefan Elzner

A method for preventing plugging of a continuous-reaction channel-system caused by a by-product of a continuous-reaction being carried out in said channel-system comprises the step of generating at least one ultrasonic wave travelling through said channel-system by coupling in a flow direction of at least one process fluid of a plurality of process fluids said at least one ultrasonic wave into said at least one process fluid.

Method for preventing plugging of a continuous-reaction channel-system and micro-reactor for carrying out the method

The invention relates to a method for the production of L-carnitine, wherein a chiral &#x3b2;-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X&#x2014;CH&#x2014;CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral catalyst.

Process for the production of carnitine by cycloaddition

The present invention relates to a process for lithium exchange reactions comprising mixing at least two fluids in a microreactor having at least two injection points.

Method for lithium exchange reactions

Method of synthesizing a compound of formula (I), wherein R1, R2 are, independently, chloro or fluoro, and wherein R3 is H, alkyl, aralkyl or is an alkylether or alkylthioether comprising the steps of firstly reducing a diazeny compound of formula (II) non-catalytically or with a catalytic amount of an homogenous organic, non-metal catalyst to the corresponding hydrazo compound of formula (III) and in a second step catalytically hydrogenating said hydrazo compound in with a heterogeneous Ni-catalyst to the compound of formula (I). 

Reduction of 5-(aryl-diazenyl)-4,6-dihalo-pyrimidine

.gamma.-Mercaptocarboxylic acids and their derivatives, in particular esters and amides, are prepared from .gamma.-butyrolactones via the corresponding thiolactones. The thiolactones are obtained by reaction of a .gamma.-lactone with thiocarboxylates in polar solvents and are converted by ring opening using nucleophilic reagents, such as, alkali metal alkoxides, into the .gamma.-mercaptocarboxylic acid derivatives. These are intermediates, for example, for the synthesis of leucotriene antagonists.

Process for preparing .gamma.-mercaptocarboxylic acid derivatives

A process for the production of 3-aminocrotononitrile by dimerization of acetonitrile. In this process, the deprotonation step takes place with sodium amide as a strong base in the presence of liquid ammonia. 3-Aminocrotononitrile is used as an initial product for the production of pharmaceutical agents, pesticides or azo dyes.

Process for the production of 3-aminocrotononitrile

Crude adenine, that is contaminated by 9-phenyladenine and/or colored additives, is converted with hexamethyldisilazane in the presence of a catalyst into N,N'-bis(trimethylsilyl) adenine, which is distilled and then reconverted into pure adenine by hydrolysis.

Process for the purification of adenine

The polymer portion in the production of diketene by the dimerization of ketene obtained from acetic acid by pyrolysis is reduced by the addition of sulfur dioxide to the ketene gas or to the reaction medium.

Process for the reduction of the polymer portion in the dimerization of

Process for the reduction of the ketene trimer portion in raw diketene by mixing of the diketene with water, an alcohol, a phenol or a carboxylic acid, and heating the mixture to 50.degree. to 130.degree. C., and then distilling off the diketene.

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Visp, Switzerland

Wilhelm Quittmann