Dyomics Gmbh

Other

Pierce Biotechnology, Inc.

Wilhelm G Frank

Matthias S Wenzel

Peter T Czerney

Frank G Lehmann

Bernd G Schweder

Surbhi Desai

Boguslawa Dworecki

Greg Hermanson

The invention concerns compounds based on benzoxazoles wherein selected substituents are each a reactive group A bound via a linker L and adapted to covalently bond a compound of the invention to a to-be-marked molecule K, wherein A is an amine, hydroxy or phosphoramidite function, a carboxylic acid, an alkyl or active ester derived therefrom; a carboxylic acid hydrazide; or a carboxylic acid amide where K is a covalently bound component selected from the group haptenes, proteins (antibodies), low molecular weight drug compounds, peptides, nucleotides, nucleosides, DNA oligomers, polymers, and t is from 1 to 10, and L is a linker selected from a group featuring &#x2014;(CH)&#x2014;, &#x2014;[(CH)&#x2014;O]&#x2014;(CH)&#x2014;, &#x2014;NR10-(CH)&#x2014;, &#x2014;O&#x2014;(CH)&#x2014;, &#x2014;S&#x2014;(CH)&#x2014;, &#x2014;NR10-C(O)&#x2014;(CH)&#x2014;, &#x2014;NR10-C(O)&#x2014;O&#x2014;(CH)&#x2014;, &#x2014;NR10-C(O)&#x2014;NR11-(CH)&#x2014; or &#x2014;SO&#x2014;NR10-(CH)&#x2014;, wherein R10 and R11 are each independently hydrogen, alkyl and alkoxy-alkyl (&#x2014;[(CH)&#x2014;O]&#x2014;CH), &#x3c9;-sulfoalkyl (&#x2014;(CH)&#x2014;SO), m represents the numbers of 2-5, p, r and s each independently represent the number of 1-10.

Marker dyes for UV and short wave excitation with high stokes shift based on benzoxazoles

Compounds used as dyes comparable to Alexa Fluor 350 dyes. The inventive compounds have high fluorescence quantum yield and high photostability. The dyes facilitate analysis of biological structures with enhanced sensitivity and selectivity.

Compounds used as dyes comperable to Alexa Fluor 350 dyes

Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labelling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diasteromeric cyanines with high hydrophilicity and other desirable properties.

Hydrophilic labels for biomolecules

Compounds having the general of formula I and/or formula II wherein Rand Rare the same or different and are independently selected from the group consisting of &#x2014;H, &#x2014;C-C-alkyl or -&#x3c9;-sulfoalkyl;

Sulfonamide derivatives of xanthene compounds

The invention relates to compounds based on merocyanines with the general formulas I and/or II, where n=0 or an integer from 1 to 3, X=O or S and the residues Rto Rare the same or different and signify in particular hydrogen or various organic residues, without or with functional groups, and Rincorporates an amine function. The compounds in accordance with the invention are suitable as fluorescent dyes (fluorophores) for used in optical determination and demonstration methods, in particular those employing fluorescence, for example in medicine, pharmacology and the biological, materials and environmental sciences. They are characterized by high photostability and long storage life, and exhibit a high fluorescence quantum yield. Excitation causing them to emit light can be achieved in a simple manner, by white-light sources or by laser irradiation in the UV, visible or NIR spectral region.

Compounds on the basis of 2- and 4-chromenylidene-merocyanines respectively, and their use

The present invention relates to the field of optical-fluorescent markers, particularly to benzopyrylo-polymethine-based optical-fluorescent markers.

Benzopyrylo-polymethine-based hydrophilic markers

A method of producing and arrangement for a multi-pane insulating glass structure which has two parallel panes, a frame for holding the panes and an adhesive sealant mounted between the panes and the frame, comprises specially-shaped elongated plastic sectional rods forming portions of the frame and having grooves for receiving the panes with a foil-type vapor seal mounted intermediate first and second ones of the sectional rod portions. The first rod portion is substantially U-shaped in cross-section and forms a spacer for the spaced parallel panes. The U-shaped sectional rod includes a central web for spanning the foil-type vapor seal and forming a chamber for housing a moisture-absorbing agent.

Multi-pane insulating glass and method for its production

A combined rolling shutter and ventilating box comprises a housing holding the rolling shutter. A ventilating box has horizontal and vertical air duct sections divided into a first duct section part receiving warm air to be exhausted from an interior room and a second duct section part receiving fresh air from the atmosphere. A ventilator exhausts the warm air through the first duct section part and the exhausted warm air is vented to the atmosphere. A fresh air inlet communicates with the second duct section and a ventilator draws the fresh air therethrough. A heat exchanger in the air duct sections extends transversely through the air flow through the first and second duct parts.

Growing community of inventors

Jena, Germany

Wilhelm G Frank