Dr. Madaus & Co.

Istituto Biochimico Italiano Giovanni Lorenzini S.p.a.

Madaus Ag

Wilfried Wachter

Helga Zaeske

Jozsef Szejtli

Enrico Bosone

Umberto Valcavi

Roberto Caponi

Vincenzo Monterosso

The present invention provides a process for the production of a flavanolignan preparation with an improved liberation in comparison with one of the pure flavanolignans, characterised in that a) an aqueous-alcoholic solution of pharmaceutically-acceptable carrier materials and wetting agents is prepared, a flavanolignan is suspended in this solution and the mixture obtained is heated to the boiling temperature in order to form a clear solution or b) a flavanolignan and a wetting agent is suspended in alcohol, the suspension obtained is heated with stirring up to the formation of a clear solution, this is mixed with an aqueous solution of pharmaceutically-acceptable carrier materials and the mixture obtained is heated with stirring until a clear solution is present and that subsequently the clear solution obtained according to a) or b) is concentrated for the formation of a co-precipitate, filtered and the resulting co-precipitate dried in a vacuum. The flavanolignan preparation can be used as medicaments for the treatment and prophylaxis of liver diseases and also as liver protection agents for the avoidance of damage by medicaments, drugs and alcohol.

Process for the manufacture of flavanolignan preparation with improved

The present invention provides a process for the production of a flavanolignan preparation with an improved liberation in comparison with one of the pure flavanolignans, characterized in that a) an aqueous-alcoholic solution of pharmaceutically-acceptable carrier materials and wetting agents is prepared, a flavanolignan is suspended in this solution and the mixture obtained is heated to the boiling temperature in order to form a clear solution or b) a flavanolignan and a wetting agent is suspended in alcohol, the suspension obtained is heated with stirring up to the formation of a clear solution, this is mixed with an aqueous solution of pharmaceutically-acceptable carrier materials and the mixture obtained is heated with stirring until a clear solution is present and that subsequently the clear solution obtained according to a) or b) is concentrated for the formation of a co-precipitate, filtered and the resulting co-precipitate dried in a vacuum. The flavanolignan preparation can be used as medicaments for the treatment and prophylaxis of liver diseases and also as liver protection agents for the avoidance of damage by medicaments, drugs and alcohol.

Process for the manufacture of flavanolignan preparations with improved

The invention relates to inclusion complexes of Silybinin with a cyclodextrin selected from the group consisting of .alpha.-, .beta.- and .gamma.-cyclodextrin and a suitable derivative thereof and to the method for the preparation thereof. The inclusion complexes of Silybinin showed a highly improved bioavailability in comparison to Silybinin which makes them particularly interesting in the treatment of various hepatotoxic conditions.

Inclusion complexes with silybinin, their preparation and pharmaceutical

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Bergisch Gladbach, Germany

Wilfried Wachter