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Board of Governors for Higher Education, State of Rhode Island and Providence Plantations

The Board of Governors for Higher Education, State of Rhode Island and

Wilfred H Nelson

Jay F Sperry

Richard A Dalterio

A system for the detection of bacteria based on bacteria-antibody complexes. Bacteria attached to antibody are detected with resonance Raman spectroscopy. The bacteria are detected directly in a great numerical excess, e.g. 100 to 10,000 of antibody molecules. A sample to be tested is placed in a medium, the medium containing antibodies attached to a surface for binding to a specific bacteria to form an antigen to antibody complex. The medium is contacted with a beam of light energy. The bacteria, as a lower resonance enhanced Raman backscattered energy, is analyzed for the presence or absence of the bacteria.

Direct detection of bacteria-antibody complexes via UV resonance Raman spectroscopy

This invention relates to a method for biodetection and identification of antibiotic susceptibility tested in bacteria by cerating spectrum against target cells and comparing them.

Antibiotic susceptibility test

A bacterial suspension is contacted by a single vavelength in the ultra-violet range. A portion of the light energy used is absorbed and a portion of the light energy is emitted. The emitted light energy, resonance enhanced Raman scattering, is measured as backscattered energy. The energy is processed to produce spectra which are characteristic of the bacteria.

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Kingston, RI, United States of America

Wilfred H Nelson