Smithkline Corporation

Smithkline Beecham Corporation

Smithkline Beckman Corporation

Sk&f Lab Co.

Wilford L Mendelson

Sidney H Levinson

Ivan Lantos

Paul G Gassman

Joseph Robert Flisak

Kevin Scott Webb

Robert L Webb

George R Wellman

Bing L Lam

Ann Marie Diederich

Elvin L Anderson

Li Liu

Jianhao Chen

Andrew Allen

Charles B Spainhour, Jr

This invention relates to a method of preparing a compound type where at least one of R&prime; or R&Prime; is a carboxyl group (I) by treating a compound of formula (II) with a Group I(a) or Group II(a) metal halide, with an aprotic dipolar amide-based solvent and water.

Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

A novel process for producing chiral hydroxylamines for use as intermediates to make chiral hydroxyureas, which process comprises a tandem condensation-cyclization reaction between a dimethylsulfoxoniurn methylide and an appropriately substituted nitrone bearing a D- or L- mannose chiral auxiliary to yield a compound of Formula (I) as claimed herein.

Large scale preparation of 2,4-dihydroxybenzaldehyde using a variation

This invention relates to a process for preparing epoxy esters, and intermediates prepared by this process, in particular, to a process which produces non-racemic epoxy esters which are of use as intermediates in the preparation of pharmaceutical compounds.

Intermediates for preparing epoxy esters

Process for preparation of epoxy esters and intermediates prepared

A method for preparing 1,2,3,4-tetrahydroisoquinolines comprising heating N-halo or hydroxyethyl-N-benzylamines in an aluminum chloride melt at 160.degree.-210.degree..

Method for preparing tetrahydroisoquinolines

A new synthesis for the preparation of 6-(2-hydrophenyl)-3-pyridazinones whose key reaction is cyclizing a 1,1,1-trihalo-2-hydroxy-4-(2-hydroxyphenyl)-4-butanone with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinones are important intermediates for preparing medicinally active compounds especially 3-[2-(3-tert.-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine or its nontoxic acid addition salts. The invention claimed here is the trihalocarbinol intermediates.

1,1,1-Trihalo-2-hydroxy-4-(2-hydroxyphenyl)-4-butanones

New 3-(o-hydroxyphenyl)-5-formylhydrazino-.DELTA..sup.2 -pyrazolines useful in the preparation of 6-(2-hydrophenyl)-3-pyridazinones which are in turn important intermediates for preparing medicinally active compounds especially 3-[2-(3-tert.-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine.

3-(o-Hydroxyphenyl)-5-formylhydrazino-.DELTA..sup.2 -pyrazolines

A new synthesis for the preparation of 6-(2-hydroxyphenyl)-3-pyridazinones whose key reaction is cyclizing a 1,1,1-trihalo-2-hydroxy-4-(2-hydroxyphenyl)-1-butanone with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinones are important intermediates for preparing medicinally active compounds.

Synthesis of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones from

An improved process for the preparation of 4-(hydroxymethyl)imidazoles by reducing 4-imidazolecarboxylic acid esters using an alkali metal or calcium in liquid ammonia with an additional proton source provided during the reaction or upon workup.

Process for preparing 4-(hydroxymethyl)imidazole compounds

A new process for preparing 2,3-dichloroanisole comprises reacting 1,2,3-trichlorobenzene with an alkali metal methoxide preferably in the presence of methanol.

Method of preparing 2,3-dichloroanisole

Lower alkyl 4-imidazolecarboxylates are electro-chemically reduced to give the corresponding alcohol and lower alkyl ethers. This mixture is reacted directly with cysteamine to give the important thioamine intermediates.

Electrochemical reduction of imidazolecarboxylic esters

Methods and intermediates are disclosed for the preparation of trifluoromethylthioacetic acid using the reaction of trifluoromethylsulfenyl halides with certain orthoesters.

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King of Prussia, PA, United States of America

Wilford L Mendelson