University of Colorado

Wilbur Franklin

Paul A Bunn, Jr

Fred R Hirsch

Mark Palmer

Mark W Geraci

Marileila Varella Garcia

Michio Sugita

Samir E Witta

Willem Berglund

Dara Aisner

Federico Cappuzzo

Qing Ren

Razvan Lapadat

Christopher D Coldren

Andrew Hanuszek

Aaron Lieberman

Stephen DeMars

Eric Kelso

Barbara A Helfrich

The present invention provides an apparatus and method for microdissecting a biological sample. In particular, apparatuses of the invention include a cell collecting devicethat is operated by a pneumatic device. In one particular embodiment, apparatuses of the invention are used for collecting and transferring cell sample to and from cell collecting device

Cell collecting apparatus and method of use

Disclosed are methods to obtain an expression score to evaluate gene expression in a tissue specimen obtained from a person having or suspected of having cancer.

Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by non-small cell lung cancer patients

Disclosed is the identification, provision and use of a panel of biomarkers that predict sensitivity or resistance to gefitinib and other EGFR inhibitors, and products and processes related thereto. Specifically, a method is described for selecting a cancer patient who is predicted to benefit from therapeutic administration of an EGFR inhibitor, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitor. Also described is a method to identify molecules that interact with the EGFR pathway to allow or enhance responsiveness to EGFR inhibitors, as well as a plurality of polynucleotides or antibodies for the detection of the expression of genes that are indicative of sensitivity or resistance to EGFR inhibitors, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitors. A method to identify a compound with the potential to enhance the efficacy of EGFR inhibitors is also described.

Gefitinib sensitivity-related gene expression and products and methods related thereto

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Denver, CO, United States of America

Wilbur Franklin