Alphavax, Incorporated

Whitney Ellis

Jonathan F Smith

Bolyn Hubby

Laura Copp

Peter Berglund

The immune response to an antigen of interest, either in purified form or expressed via an alphavirus replicon particle, can be enhanced by the simultaneous administration of an alphavirus replicon particle which expresses interleukin-12. This allows for the use of significantly smaller quantities of the antigen and this immunization strategy can also eliminate the need for boosting administration of the antigen or it can reduce the number of boosts required for an effective immune response to the antigen.

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Oxford, NC, United States of America

Whitney Ellis