Northwestern University

Exicure, Inc.

Weston Daniel

Chad A Mirkin

David A Giljohann

Sergei M Gryaznov

C Shad Thaxton

Joshua I Cutler

Christopher C Mader

Richard Kang

Ke Zhang

Dan Zheng

Tiffany L Halo

Scott Mix

TNF&#x3b1; antisense oligonucleotides are provided herein. Methods of treating TNF&#x3b1; diseases or Initial Screen of Phosphodiester disorders using the TNF&#x3b1; antisense oligonucleotides and related products are provided.

Anti-TNF compounds

Optimized inhibitory nucleic acids are provided. The nucleic acids have sequences which include an optimal inhibitory motif, such as a GGG. Related methods are also described.

Nucleic acid nanostructures with core motifs

TNF&#x3b1; antisense oligonucleotides are provided herein. Methods of treating TNF&#x3b1; diseases or disorders using the TNF&#x3b1; antisense oligonucleotides and related products are provided.

The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.

Templated nanoconjugates

Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels.

Nanostructure suitable for sequestering cholesterol and other molecules

Articles, compositions, kits and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids, and an apolipoprotein may be bound to at least the outer surface of the shell. In some embodiments, the structures, when introduced to a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels.

Growing community of inventors

Evanston, IL, United States of America

Weston Daniel