General Electric Company

Global Life Sciences Solutions USA LLC

Whatman International Limited

General Electric Corporation Gmbh

Qiagen Healthcare Biotechnologies Systems Gmbh

Global Life Sciences Solutions Operations UK Ltd

Weston Blaine Griffin

Reginald Donovan Smith

Chengkun Zhang

Kashan Ali Shaikh

Vandana Keskar

Xiaohua Zhang

Ying Mao

Douglas Glenn Wildes

Warren Lee

Philip Alexander Shoemaker

Alex David Corwin

Brian Michael Davis

Erin Jean Finehout

Xuefeng Wang

Yi Xu

Reinhold Bruestle

Younkoo Jeong

Eugene Pauling Boden

Huan Tan

Venkat Subramaniam Venkataramani

Daniel Jason Erno

Zhipeng Zhang

Kenneth Roger Conway

Balajee Kannan

Lynn Ann DeRose

Minfeng Xu

James Mitchell White

Cynthia Elizabeth Landberg Davis

Jeffrey Michael Ashe

Pierino Gianni Bonanni

Erik Leeming Kvam

David Martin Mills

Vernon Jensen

Hrishikesh Keshavan

Prabhjot Singh

Arvind Rangarajan

Christopher Allen Nafis

Andrew Michael Leach

Ralf Lenigk

Zhen Liu

Dan Harris

Jaydeep Roy

Jim Dowling

Greg Darryl Goddard

Dan O'Sullivan

Donald Joseph Buckley

Susumu Mine

Ye Bai

William Patrick Waters

Eric Douglas Williams

Anshika Bajaj

Mark Robert Timmins

Austin Lines

Spencer Lovette

Krystal Burger

David Robinson

Phillip Alexander Shoemaker

James Enrico Sabatini

Murtuza Lokhandwalla

Dun Alex Li

Christopher Robert Hazard

David Andrew Shoudy

Craig Patrick Galligan

Nichole Lea Wood

Evelina Roxana Loghin

Brian W Lasiuk

David A Schuelke

Terry Michael Topka

Stefan Rakuff

Owen Scott Quirion

Pei-Hsin Kuo

Peter S Allison

Ian Hart

Diego Quinones

Ryan Austin Hutchinson

David Schuelke

Ferdinand Puttinger

Robert Jeffrey Pieciuk

Xianqiao Tong

Greg D Goddard

Erin Finehout

Kashan A Shaikh

Erick Leeming Kvam

Disclosed herein is a cell harvesting instrument suitable for concentrating cells from a source suspension of cells and/or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump, at least one valve; and a processing kit removably insertable into the housing, said kit including a generally flat frame having or supporting plural sealed fluid paths arranged in a generally flat plane and such that fluids in the paths do not contact said mechanical elements, wherein at least portions of the fluid paths comprise flexible tubes, the outer surfaces of which are manipulatable by the or each fluid pump, to provide fluid flow in one or more of the paths and/or by the or each valve to restrict fluid flow in one or more of the paths. In an embodiment, the kit comprises also a fluid processing reservoir and a filter suitable for separating cells from fluid in said paths. A transfer mechanism for moving and weighing the fluid processing reservoir is disclosed also.

Cell harvesting apparatus

In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.

Apparatus for fluid line management in a bioprocessing system

A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.

System and method for fluid flow management in a bioprocessing system

Apparatuses and methods for cutting a sample piece, having a shape and an outer dimension, out of a porous substrate, comprising: a puncher having an outermost dimension at a punch head; a stripping sleeve; a die having an innermost dimension that is larger than the outermost dimension of the punch head; and a fixture that holds the die in a fixed position relative to the puncher and stripping sleeve.

Apparatuses and methods for cutting porous substrates

Disclosed herein is an instrument suitable for processing cells for example culturing, concentrating or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump; and a disposable processing kit complementary to the mechanical elements within the housing and comprising a fluid circuit including a fluid reservoir and plural fluid paths capable of carrying fluid flow caused by said pump(s), the instrument further including a mechanism for determining the quantity, or change in quantity of the fluid in the reservoir resulting from said fluid flow, the instrument yet further comprising a controller operable to control at least the pump and operable to perform a fault determination process, which includes the steps of determining the expected flow rate of said pump(s) calculated from the speed of the pump(s) and comparing that expected flow with the change in quantity of the fluid in the reservoir as determined by said mechanism.

Instruments for processing cells

An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.

Bioprocessing apparatus

A bioprocessing system includes a first module configured for enriching and isolating a population of cells, a second module configured for activating, genetically modifying, and expanding the population of cells, and a third module configured for harvesting the expanded population of cells.

Systems and methods for bioprocessing

The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.

Patient-specific neuromodulation alignment structures

Disclosed herein is a cell harvesting instrument suitable for concentrating cells from a source suspension of cells and/or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump, at least one valve; and a processing kit removably insertable into the housing, said kit including a generally flat frame having or supporting plural sealed fluid paths arranged in a generally flat plane and such that fluids in the paths do not contact said mechanical elements, wherein at least portions of the fluid paths comprise flexible tubes, the outer surfaces of which are manipulateable by the or each fluid pump, to provide fluid flow in one or more of the paths and/or by the or each valve to restrict fluid flow in one or more of the paths. In an embodiment, the kit comprises also a fluid processing reservoir and a filter suitable for separating cells from fluid in said paths. A transfer mechanism for moving and weighing the fluid processing reservoir is disclosed also.

A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.

Systems for utilizing crossflow filtration for cell enrichment

A bioreactor vessel includes a bottom plate, a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween, and a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin on a bed plate for aligning the bioreactor vessel on the bed plate.

Bioprocessing vessel

Growing community of inventors

Niskayuna, NY, United States of America

Weston Blaine Griffin