Abbvie Inc.

W. R. Grace Co.-conn.

Westin H Morrill

Kirill A Lukin

Russell Drew Cink

David R Hill

Michael J Abrahamson

Marvin Robert Leanna

Jianzhang Mei

Dennie S Welch

Gang Zhao

Timothy B Towne

Kenneth M Engstrom

Richard D Bishop

Matthew M Ravn

Jeff M Kallemeyn

Matthew J Pelc

Erik C Carlson

Michael C Standen

The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

Synthetic route to anti-viral agents

Provided are crystalline forms of nicotinamide riboside, including a Form I of nicotinamide riboside chloride according to formula (I). Also disclosed are pharmaceutical compositions comprising the crystalline Form I of nicotinamide riboside chloride, and methods of producing such pharmaceutical compositions. In other aspects, the present disclosure pertains to methods comprising administering to a subject the crystalline Form I of nicotinamide riboside chloride. The present disclosure also provides methods of preparing the crystalline Form I of nicotinamide riboside chloride. Also provided are a crystalline Form I of nicotinamide riboside chloride that is prepared according to any of the disclosed methods for preparing the crystalline Form I.

Crystalline form of nicotinamide riboside

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Grayslake, IL, United States of America

Westin H Morrill