Agilent Technologies, Inc.

Wesley Miles Norman

Wei J Song

Matthew Spangler Klee

William H Wilson

Bruce Douglas Quimby

Li Xu

Richard P White

George P Walsh

Jonathan Michael Frentzel

William James Emmons

Wen-Yi Ge

Wenyi Ge

The present disclosure relates generally to a chromatography column adaptor for forming a fluidic connection between a chromatography column and a GC component. The present disclosure also relates to fluidic connections for a gas chromatography system.

Chromatography column adaptor and use for fluidic connections

A collet includes a cap, a conduit grasper, a collet bore, and a collet slot. The grasper is composed of a flexible material such that the grasper is compressible in response to an applied force. A conduit such as a column is installed in a fluidic component by passing the conduit through the collet and into a fluidic coupling device. The collet is then coupled to the fluidic coupling device so as to compress the grasper against the column, thereby securing the column in the fluidic coupling device. The conduit may then be inserted into the fluidic component, and fluidic coupling device may be coupled to the fluidic component to complete the conduit installation. The collet or at least the cap may then be removed by moving the collet or at least the cap around the column via the collet slot. The grasper may be removed via a grasper slot.

Collet, devices, and methods for installation of fluidic conduits to fluidic components

A fitting assembly () is provided. The fitting assembly () comprises a holder () that holds one or more fluidic seal assemblies. The fluidic seal assembly comprises a fitting (), a ferrule () and a tube (), such as a chromatography column, and optionally comprises a protrusion () and a compliant seal material (). Fluidic connections for a gas chromatography instrument are also provided.

Fitting assemblies for fluidic connections

A ferrule includes a body surrounding a bore that provides a fluid path along a central axis between a first end and a second end of the ferrule. The body includes a conical section configured for forming a sealing interface with a fitting in which the ferrule may be inserted and a sealing interface with a tube that may be inserted in the ferrule bore. The conical section includes collapse zones configured to collapse in a direction along the central axis in response to axial compression of the ferrule against the fitting. The collapse zones mitigate crushing of the ferrule against the tube. The collapse zones may be provided by a sealing region at the nose of the ferrule and annular grooves on the ferrule.

Ferrule with features for softening ferrule crush and related methods

Ferrule

A representative embodiment is directed to a fitting for fluidically coupling a GC column to another structure. The fitting comprises: a first end configured to receive a ferrule having a tubular element disposed therein, the tubular element being oriented in a first direction; and a second end fluidically connected to the first end and having an opening to provide a fluid from the tubular element in a second direction that is different from the first direction. The second end comprises a substantially planar portion, and the planar portion is configured to make a substantially gas impermeable seal with another element of a GC system.

GC column connection with a planar connection to mating devices

A connector element for use with analytical devices is provided. The connector element includes a cavity for receiving a sealing member, and an access element for providing access to the sealing member when disposed in the cavity, e.g., for dislodging the sealing member from the connector element. Also provided are analytical devices that include the connector element, as well as methods of using the same.

Connector for analytical devices

A seal forming a fluid tight connection between a gas chromatography column and a sample inlet assembly is disclosed. The seal is formed by a metal injection molding process. The seal has a first surface adapted for sealing with the sample inlet assembly and a second surface adapted for sealing with the column. The seal has an aperture extending between the first and second surfaces. A method of sealing a connection between a gas chromatography sample inlet assembly and a gas chromatography column is also disclosed. The method includes providing a seal as described above, compressing the first surface of the seal against an end of the inlet assembly, positioning the column in fluid communication with the aperture, and engaging the column with the second surface.

Seal for gas chromatography

The invention provides a low mass and size thermal focusing device for a gas phase analytical device. The device has two or more plates bonded together. The device also has at least one channel with an entrance and exit is formed within allowing ingress and egress of a gas stream. The device also has a temperature reduction module in thermal contact with at least one plate of the device. Thermal focusing devices with additional plates and/or channels are also disclosed.

Growing community of inventors

Landenberg, PA, United States of America

Wesley Miles Norman