The State University of New York

Wesley L Hicks, Jr

Joseph A Gardella

Frank V Bright

Terrence G Vargo

Rena Bizios

Alexander N Cartwright

Robert Hard

Jamson S Lwebuga-Mukasa

Bahattin Koc

Timothy Koloski

Won-Ki Lee

Ilario Losito

The present invention provides a reepithelialization/wound healing implant device comprising a barrier layer and one or more polymer layers doped with agents that promote one or more processes in reepithelialization/wound healing. The implant: [a] provides a temporary mechanical/chemical barrier to species within the external environment that inhibit epithelial migration (e.g., unbalanced production/expression of granulation tissue, inhibitory proteins); [b] biodegrades at an appropriate rate while tissue remodeling is occurring; and [c] delivers active cytokines and growth factors in a choreographed pattern to promote reepithelialization.

Resorbable laminated repair film and method of using same

The present invention relates to an in vitro cell culture device which includes a vessel comprising an inner surface, a layer of cartilage disposed on at least a portion of said inner surface, the layer of cartilage including a plurality of chondrocytes in an extracellular matrix, and a growth medium in the vessel, the layer of cartilage being bathed in the growth medium. Also disclosed is a composite cell culture prepared from the in vitro cell culture device, the composite cell culture includes a first layer including chondrocytes in an extracellular matrix, a second layer disposed on the first layer and including type I collagen, and a third layer disposed on the second layer and including cells at least partially covering the second layer. Further aspects of the present invention relate to methods of preparing an in vitro composite cell culture, methods of screening putative therapeutic agents for activity in promoting re-epithelialization of cartilaginous tissues, and methods of screening putative therapeutic agents for activity in inhibiting growth factors or proteinases.

In vitro cell culture device including cartilage and methods of using the same

The present invention provides novel surface modified biodegradable polyesters having fluorocarbon chains at the terminal end of the polyesters. The compounds of the present invention are obtained by the addition of fluorocarbon chains at the surface of the polyester. Any commonly used polyester material can be used in the present invention; however, polyglycolic or polylactic acids or co-polymers thereof are preferred.

Fluorocarbon end-capped polymers and method of synthesis

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Angola, NY, United States of America

Wesley L Hicks, Jr