Pfizer Corporation

Wesley Dewitt Clark

James F Blake

Shelley Allen

Li Ren

David A Moreno

Mark Laurence Boys

Joshua Ryan Dahlke

Jacob Matthew O'Leary

Alex Andrew Kellum

Patrick Michael Doerner Barbour

Connor James Cowdrey

Sydney Taylor Blanche

Ellen Margaret Knapp

Jennifer Lynn Fulton

Faith Elizabeth Witkos

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R, R, Rand Rare as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-diones as MEK inhibitors

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Gales Ferry, CT, United States of America

Wesley Dewitt Clark