Gruenenthal Gmbh

Werner Winter

Oswald K Zimmer

Ivars Graudums

Helmut Heinrich Buschmann

Stephan Wnendt

Werner P Vollenberg

Kai Zwingenberger

Erwin O Kiesewetter

Gerriet K Loschen

Peter Jansen, Deceased

Elmar Josef Friderichs

Wolfgang Werner Strassburger

Johannes Schneider

Michael Finkam

Ulrich G Seipp

Uwe Teubert

Michaela Akermann

Ulrich G Seippl

Thomas Kohnen

Wolfgagn Werner Strassburger

Ernst Frankus

Elmar Josef Friederichs

Acylated n-hydroxy methyl thalidomide prodrugs with immunomodulator action

Compounds analogous to thalidomide from the class comprising piperidine-2,6-diones are described, as are a method of preparing them and their use in drugs.

Compounds analogous to thalidomide from the class comprising

A method of preparing (3-alkoxyphenyl)magnesium chlorides and the use thereof for reaction with certain carbonyl compounds are described.

Preparation and use of (3-alkoxy-phenyl) magnesium chlorides

1-phenyl-2-dimethylaminomethyl-cyclohexan-1-ol compounds, methods of preparing them and the use of these compounds in drugs are described.

1-phenyl-2-dimenthylaminomethyl-cyclohexan-1-ol compounds as

A method of preparing the enantiomers of O-demethyltramadol and the use of the enantiomers as pain-killing drugs are described.

Method of preparing the enantiomers of O-dimethyltramadol

A method of separating the racemate of tramadol is disclosed.

Method of separating the racemate of tramadol

Phenol derivatives of the formula ##STR1## wherein A and B have the same or different meanings and each represent one of the groups --C.tbd.C--, cis--CH.dbd.CH-- or trans--CH.dbd.CH--, R.sub.1 is hydrogen, an optionally substituted alkyl or phenyl group or a cycloalkyl group, R.sub.2 is hydrogen, methyl or ethyl, R.sub.3 represents hydrogen, acetyl or propionyl, R.sub.4 has the same meaning as R.sub.3 or represents an alkyl group, R.sub.5 is a carboxylic or a hydroxy group or a functional derivative of such groups or R.sub.5 is a nitrile group and R.sub.6 is hydrogen, an alkyl group or the group OR.sub.4 which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leukotrienes. The compounds are prepared by reacting suitable acetylene compounds or metal derivatives thereof with alkyl or aryl halides or by means of Wittig reactions optionally followed by transforming the member R.sub.5 into another carboxylic acid derivative. By hydrogenation A and B may be varied within the scope of the definition.

Phenol derivatives, pharmaceutical compositions containing these

Phenol derivatives and pharmaceutical compositions containing these

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Aachen, Germany

Werner Winter