Boehringer Mannheim Gmbh

C.f. Boehringer & Soehne Gmbh

Werner Winter

Androniki Roesch

Max Thiel

Walter-Gunar Friebe

Otto-Henning Wilhelms

Wolfgang Schaumann

Egon Roesch

Kurt Stach, Deceased

By Werner Plattner, Administrator

Wolfgang Kampe

Gisbert Sponer

Kurt Stach

Karl Dietmann

Herman Hindermayr

The present invention provides aryl ether derivatives of the general formula: ##STR1## wherein A is an oxygen atom or the group &gt;N--R.sub.1, R.sub.1 being a hydrogen atom or a lower alkyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl radicals, R.sub.4 is a hydrogen atom or a hydroxyl group, R.sub.5 is a hydrogen atom or an acyl radical, R.sub.7 is a hydrogen atom, a lower alkyl radical or a lower alkanoyl radical and R.sub.8 is a hydrogen atom, a lower alkyl radical, a lower alkoxy radical or a hydroxyl group; and the pharmacologically acceptable salts thereof. The present invention also provides a process for the preparation of these compounds and pharmaceutical compositions containing them. It is also concerned with the use of these compounds for combating allergic diseases.

1,2-Dihydroquinolines connected via an oxyalkyl group with a piperidine

An aryl ether derivative of the formula ##STR1## in which A is an oxygen atom or an &gt;N--R.sub.1 grouping,

Anti-allergic aryl ether derivatives

Coumarins connected via an oxyalkyl group with a piperidine ring having

A (4-substituted-piperazin-1-yl)-alkoxy-2-oxo-1,2-dihydroquinoline of the formula: ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 each independently is hydrogen or a lower alkyl radical,

1,2-Dihydroquinoline-2-one derivatives

Anti-allergy novel 1-oxo-1H-pyrimido[6,1-b]benzthiazole derivatives of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each independently is hydrogen, halogen, hydroxy, nitro, trifluoromethyl, or lower alkyl, alkoxy or alkylthio, or

1-Oxo-1H-pyrimido[6,1-b]benzthiazole derivatives

Benzopyrones of the formula ##STR1## wherein R.sub.1 is a hydrogen or halogen atom or a hydroxyl, lower alkyl, alkoxy, alkylthio or trifluoromethyl radical,

Benzopyrone derivatives exhibiting anti-allergic activity

Novel tricyclic aminoalkyl derivatives are disclosed which are characterized by valuable pharmacological activities and namely by cardiac and circulatory activities. The tricyclic aminoalkyl derivatives are compounds of the formula: ##STR1## wherein X is an oxygen or a sulfur atom, a saturated or unsaturated, straight chain or branched alkylene group containing up to 3 carbon atoms, an oxymethylene, thiamethylene or thiaethylene group or a valency bond, R.sub.1 is hydrogen, halogen, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen or hydroxyl, R.sub.3 is hydrogen or together with R.sub.2 represents a further valency bond, R.sub.4 and R.sub.5 which may be the same or different are each hydrogen or lower alkyl, A is alkylene which is substituted by an optionally acylated hydroxyl group, Y is an oxygen or sulfur atom or an optionally alkylated imino group and Z is aryl, aralkyl, cycloalkyl or cycloalkyl-alkyl which may be substituted by halogen, hydroxyl, nitro, amino, alkoxy, aralkoxy, alkyl, trifluoromethyl, alkylamino or alkylsulfonyl group, and the acid addition salts thereof with pharmacologically acceptable acids.

Tricyclic aminoalkyl derivatives

A N.sup.6 -substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenine of the formula ##STR1## wherein R.sub.1 is hydrogen or a lower alkyl radical, and

N.sup.6 -Substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenines

New tricyclic substituted aminoalcohols of the formula: ##SPC1## Wherein

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Heppenheim, Germany

Werner Winter