Biochemie Gesellschaft M.b.h

Sandoz Gmbh

Werner Veit

Johannes Ludescher

Hubert Sturm

Martin Decristoforo

Heinrich Thaler

Gerd Ascher

Siegfried Wolf

Bernhard C Prager

Karl Wessely

Ludwig Miller

Processes for the depletion of 7-ADCA in mixtures of vinyl-ACA with 7-ADCA via novel salts of vinyl-ACA or via chromatography.

Purification process

Process for purification of a cephalosporin derivative

Crystalline 2-(amninothiazol-4-yl)-2-(tert.butoxycarbonylmethoxyimino)acetic acid-S-mercapto-benzo-thiazolylester in form of an N,N-dimethylacetamide solvate; a crystalline salt of a 7-&lsqb;2-(aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido&rsqb;-3-vinyl-3-cephem-4-carboxylic acid with an amine of formula N(R,)(R,)(R,), wherein R,, R,, and R,have various meanings, a crystalline sulphuric acid addition salt of a 7-&lsqb;2-(2-aminothiazol-4-yl)-2-carboxymethoxyimino)acetamido&rsqb;-3-vinyl-3-cephem-4-carboxylic acid; and the use of these salts in the production of cefixime, e.g. in form of a trihydrate.

A process for purification of vinyl-ACA of formula

Vinyl-ACA purification process

A cephalosporin intermediate of the formula ##STR1## where R.sub.3 is carboxyl, carboxylate, or a carboxylic acid ester group and,

Cephalosporin intermediate products

Compound of formula IVe ##STR1## where Het is 2-pyridyl or 2-benzothiazolyl, are useful as acylating agents in preparing 7-[2-(2-amino-4-thiazol)-2-oxoacetyl]-cephalosporin intermediates.

2-(2-aminothiazol-4-yl)-2-oxoacetic acid derivatives

The invention relates to new stable, crystalline forms of the t-butylester of ceftazidime of formula ##STR1## and the production thereof.

Stable, crystalline form of a cephalosporin intermediate product

Disclosed is a method for producing 1-naphthol-4-sulphonic acid in free acid form and contaminated with less than 2% by weight of the isomeric 1-naphthol-2-sulphonic acid.

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Kufstein, Austria

Werner Veit