Mars, Incorporated

Georgetown University

University of Illinois

University of Il

Psycogenics Inc.

Werner Tueckmantel

Alan P Kozikowski

Leo J Romanczyk

Gian Luca Araldi

Marc E Lippman

Darryl Hugh Steensma

Po-wai Yuen

Anatoly Dritschilo

Jayaraman Chandrasekhar

Mira Jung

Joel R Walker

Pavel A Petukhov

Arsen Gaysin

Hongbin Yuan

Yufeng Chen

Jianhua Liu

One aspect of the invention relates to isoform-selective HDAC inhibitors. Also provided are methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy. The invention also provides methods for treating cancer, methods for treating neurological diseases and methods for treating malaria. Additionally, the invention provides pharmaceutical compositions comprising an HDAC inhibitor of the invention; and kits comprising an HDAC inhibitor of the invention.

Isoform selective HDAC inhibitors

The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand.

Nicotinic acetylcholine receptor ligands and the uses thereof

A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.

Synthetic methods for polyphenols

The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and methods for their use.

Bicyclic metabotropic glutamate receptor ligands

The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and and methods for their use.

Synthetic methods for preparation of protected proanthocyanidin(s)

A process is disclosed for the production of polyphenol oligomers having n polyphenol monomers, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomers. Advantageously, polyphenol monomers forming the polyphenol oligomers may be the same or different.

Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives

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Washington, DC, United States of America

Werner Tueckmantel