Boehringer Ingelheim Gmbh

Boehringer Ingelheim Kg

C. H. Boehringer Sohn

Werner Traunecker

Kurt Schromm

Anton Mentrup

Herbert Koppe

Werner Kummer

Ernst-Otto Renth

Helmut Stahle

Wolfgang Hoefke

Gojko Muacevic

Walter Losel

Richard Reichl

Herbert Merz

Ludwig Pichler

Franz Esser

Franz J Kuhn

Otto Roos

Karl Zeile

Albrecht Engelhardt

Wilhelm Frolke

Hans P Kollmer

Heinrich Kreuzer

Gojko Mualcevic

Ernst Otto Renth

Compounds of formula ##STR1## wherein the substituents are defined hereinbelow, useful in the treatment of bronchospasm are described.

New quaternary ammonium compounds, their preparation and use

The invention relates to a compound of the formula ##STR1## wherein R.sub.1 is a linear or branched alkyl of 4 to 20 carbon atoms;

1-(Alkanoylamino-aryloxy)-2-hydroxy-3-(alkinyl-amino)-propanes and salts

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms or trifluoromethyl;

1-(6,7-Dimethoxyquinazol-4-yl)semicarbazides

Lipolytic pharmaceutical composition containing 1-(4-hydroxy-3-dimethylamino-sulfonamidophenyl)-1-hydroxy-2-(1-phenoxy-iso propylamino)ethane or a pharmaceutically acceptable acid addition salt thereof as the active ingredient, and a method of combatting obesity therewith.

Lipolytic composition and method of treating obesity

Compounds of the formula ##STR1## wherein R.sub.1 is cycloalkyl of 3 to 10 carbon atoms; phenyl; mono- or poly-substituted phenyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkenyloxy, lower alkinyl, nitro, trifluoromethyl, hydroxyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the phenyl ring; aryloxy-lower alkyl; (mono- or poly-substituted aryl)-oxy-lower alkyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, acyl, acyloxy, nitro, trifluoromethyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the aryl ring;

1-Aryloxy-3-alkinylamino-propan-2-ols

Compounds of the formula ##STR1## wherein R.sub.1 is cycloalkyl of 3 to 10 carbon atoms; phenyl; mono- or poly-substituted phenyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, lower alkinyloxy, lower cycloalkyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the phenyl ring; aryloxy-lower alkyl; (mono- or poly-substituted aryl)-oxy-lower alkyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, lower alkinyloxy, lower cycloalkyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the phenyl ring;

1-Aryloxy-3-alkylamino-propan-2-ols

This invention relates to compounds of the formula ##STR1## wherein R.sub.1 represents a linear or branched alkyl of from 1 to 20 carbon atoms;

1-Aryloxy-3-alkylamino-2-propanols and pharmaceutical compositions

Racemic or optically active compounds of the formula

Aminoalkyl-substituted heterocycles

This invention relates to a compound of the formula ##STR1## wherein R.sub.1 is ethyl or isopropyl;

This invention relates to substituted 1-(.alpha.-aminocarbonyl-benzyl)-3,4-dihydro-isoquinolines in the racemic or optically active form and the non-toxic pharmacologically acceptable salts thereof. These compounds are useful in the promotion of blood circulation in warm-blooded animals.

Substituted 1-(.alpha.-aminocarbonyl-benzyl)-3,4-dihydro-isoquinolines,

Racemic and optically active compounds of the formula

Aminoalkyl-substituted benzimidazolidin-2-ones

Aminoalkyl-substituted benzoxazine derivatives

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, --(CH.sub.2).sub.n --R.sub.4 or --CO--R.sub.5, where n is 1 or 2,

Hypertensive phenylalkylamines and salts thereof

Compounds of the formula ##STR1## wherein R.sub.1 is alkyl of 6 to 19 carbon atoms, and

1-(M-alkanoyloxy-phenyl)-1-hydroxy-2-(N-lower alkyl-amino)-ethanes and

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl, and R.sub.2 is phenoxy-(alkyl of 2 to 3 carbon atoms), phenyl-(alkyl of 4 to 5 carbon atoms), hydroxyphenyl-(alkyl of 3 to 5 carbon atoms), or naphthyl-(alkyl of 4 to 5 carbon atoms); And their non-toxic, pharmacologically acceptable acid additions salts; the compounds as well as the salts are useful as dilators of the peripheral blood vessels, as cardiotonics and as broncholytics.

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Munster-Sarmsheim, Germany

Werner Traunecker