Helmholtz-zentrum Fuer Infektionsforschung Gmbh

Gesellschaft Fuer Biotechnologische Forschung Mbh (gbf)

Gesellschaft Fuer Biotechnologische Forschung Mbh

Helmholtz-zentrum Fur Infektionsforschung Gmbh

Werner Tegge

Ronald Frank

Carlos Alberto Guzman

Michael Morr

Thomas Ebensen

Stephan Hüttel

Mark Broenstrup

Mark Brönstrup

Verena Fetz

Stephan Huettel

Philipp Klahn

Wera Collisi

Katrin I Mohr

Joern Gloekler

Rainer Gast

The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in connection with drug conjugates. The present invention further relates to new ratjadone compositions including the aforementioned payloads, payload-linkers and drug conjugates, and methods for using these payloads, payload-linkers and drug conjugates, to treat pathological conditions including cancer, inflammatory and infectious diseases.

Targeted cytotoxic ratjadone derivatives and conjugates thereof

The present invention relates to new lipopeptide- and lipoprotein molecules and lipopeptide- and lipoprotein-conjugates. In particular, the present invention relates to new lipopeptide- and lipoprotein molecules and lipopeptide- and lipoprotein-conjugates comprising a lipid-containing moiety representing an adjuvant moiety, a peptide or protein moiety whereby said peptide or protein moiety represents at least one antigenic structure, the antigen-moiety, and, optionally, a conjugate moiety, preferably a monodisperse polyethyleneglycol unit. Said compounds are particularly useful for therapeutic or prophylactic vaccination by mucosal or systemic administration, preferably mucosal and systemic vaccination. That is, the present invention relates in another aspect to pharmaceutical compositions comprising the compounds according to the present invention, in particular, said pharmaceutical compositions are vaccines. In addition, said pharmaceutical compositions are useful for the prophylaxis or treatment of infectious diseases, inflammatory and autoimmune diseases, cancer, allergies or for the control of fertility in human or animal populations.

Lipopeptide- and lipoprotein-conjugates and its use

The present invention refers to a method for attaching substrate molecules to gel matrices, characterized in that a substrate is covalently bound to a monomeric or oligomeric constitutional unit of a gel and the resultant product is polymerized. The present invention further refers to gels obtainable by this process.

Immobilized substrate, separation gels and method for detecting enzymatic activity

Complexes, especially for the detection and separation of phosphoric-ester-containing compounds, are disclosed. The complexes according to the invention comprise at least one chelating agent, at least one central atom or central ion coordinated by the chelating agent(s), and at least one dye bonded to the chelating agent(s), etc.

Compounds for detecting phosphoric acid esters

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Braunschweig, Germany

Werner Tegge