Behringwerke Aktiengesellschaft

Hoechst Aktiengesellschaft

Dade Behring Marburg Gmbh

Behringwerke Aktiengellschaft

Werner Stuber

Robert Ziegelmaier

Leszek Wieczorek

Jochen Knolle

Gerhard Breipohl

Cenek Kolar

Dieter Schnaitmann

Michael Kraus

Karl Fickenscher

Mathias Fibi

Hermann Pelzer

Gerhard Dickneite

Eric P Paques

Jurgen Romisch

Hartmut Lobermann

Rainer Koschinsky

Eric-Paul Paques

The invention relates to peptides for the immunochemical determination of human cytomegalovirus (HCMV)-specific antibodies and HCMV antigens, and to agents suitable for this method and to the use thereof.

HCMV-specific peptides, agents therefor and the use thereof

The present invention is directed to the generation of antibodies which preferentially bind to fibrinogen fragments E1, E2, and E3, but exhibit little or no cross-reactivity against fibrin monomer and fibrinogen. Thus, the invention provides synthetic peptides containing defined amino acid sequences corresponding to the carboxy terminal regions of the E fragments which arise as a result of plasmin cleavage of fibrin and fibrinogen. The synthetic peptides may be synthesized chemically, or through genetic manipulations, and may contain additional amino acid sequences which are not contiguous with the defined E fragment sequences.

Synthetic peptides, antibodies against them and their use

The invention relates to a DNA sequence which encodes three specific human cytomegalovirus (HCMV) peptides of the pp150 protein. These peptides are shown to have novel immunogenic properties. The DNA sequence is also used in a method of hybridization for the detection of fully complementary sequences.

DNA sequences which encode immunoreactive HCMV-specific peptides

Erythropoietin (EPO) peptides and the use thereof for preparing epitope-specific anti-EPO antibodies are described. Also described are corresponding anti-EPO antibodies which take the form of polyclonal antibodies (antisera) or of monoclonal antibodies. These antibodies are suitable for purifying EPO, EPO derivatives or EPO peptides. The epitope-specific anti-EPO antibodies according to the invention can also be used for the detection of EPO and, in particular, for the epitope-specific detection of EPO. Additionally described are anti-idiotype antibodies which imitate a receptor region of EPO. Finally, pharmaceuticals which contain the EPO peptides, anti-EPO antibodies or anti-idiotype antibodies, and diagnostic aids for the detection of EPO or of anti-EPO antibodies, are described.

Erythropoietin (EPO) peptides and antibodies directed against these

Peptide amides of the formula I (SEQ ID NOS: 3-21)

Peptide amides, processes for the preparation thereof and agents

The invention relates to antibodies which react with fibrinogen fragments E1, E2 and E3 raised by immunizing with a peptide. The invention also relates to assay methods for proteins containing an epitope which is common to fibrinogen fragments E1, E2 and E3 using these antibodies.

Antibodies which react with fibrinogen fragments E1, E2 and E3 and

Glycopeptide derivatives, a process for their preparation and pharmaceutical agents containing these compounds N-Glycopeptide derivatives of the formula I ##STR1## where aromatic is an unsubstituted or substituted benzene residue, naphthalene residue, chroman residue, chromene residue or coumarone residue,

Glycopeptide derivatives, a process for their preparation and

Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.

Amidinophenylalanine derivatives, a process for the preparation thereof,

Compounds of the formula I ##STR1## in which X denotes a hydrogen atom, a group which irreversibly masks the terminal amino group, or a protecting group which is conventional in peptide chemistry, such as, for example, Boc-, Z- or Fmoc-,

Chromogenic method of detecting endoproteases

The invention relates to synthetic peptides which contain certain partial sequences from factor VIIa, the synthesis thereof and the use of these peptides for immunizing an animal and for purifying specific antibodies against the said peptides, to antibodies against these peptides and the use of these antibodies and peptides in therapy and diagnosis.

Synthetic peptides which contain sequences from factor VIIa, and the use

A method for the detection and for the determination of blood coagulation factor XIII in plasma, as well as a kit containing means which can be used in this method, are described. Used in this method are a fibrin-aggregation inhibitor, thrombin, a glutamine-containing peptide as substrate for factor XIII, an amine and a system for detecting ammonia which is formed. The kit containing means which can be used in this method contains a fibrin-aggregation inhibitor and a glutamine-containing peptide, where appropriate in addition to other components necessary for the method.

Method and a kit containing means for the kinetic determination of

Protease absorbent for isolating and purifying proteases, a process for

The invention relates to new compounds of the formula ##STR1## in which R.sup.1 denotes (C.sub.1 -C.sub.8)-alkyl, R.sup.2 denotes an amino acid residue which is protected with a urethane protective group which can be eliminated with weak acid or base, or denotes an amino protective group which can be eliminated with weak acid or base, R.sup.3 denotes hydrogen or (C.sub.1 -C.sub.4)-alkyl, and Y.sup.1 -Y.sup.9 denote identical or different radicals hydrogen, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy or --O--(CH.sub.2).sub.n --COOH (with n=1 to 6), with one of these radicals being --O--(CH.sub.2).sub.n --COOH, or Y.sup.1, Y.sup.2 and Y.sup.5 -Y.sup.9 denote identical or different radicals hydrogen, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkoxy, Y.sup.3 denotes hydrogen or (C.sub.1 -C.sub.8)-alkoxy and Y.sup.4 denotes --(CH.sub.2).sub.n --COOH or --NH--CO--(CH.sub.2).sub.n --COOH (with n=1 to 6). Processes for the preparation thereof and the synthesis of peptide amides by a solid-phase method using these new compounds (spacers) are described.

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Lahntal, Germany

Werner Stuber