Other

National Taiwan University

Uwm Research Foundation, Inc.

Medical University of Vienna

University of Belgrade—faculty of Pharmacy

Werner Sieghart

Robert H Dodd

Pierre Jean-Paul Potier

Miroslav M Savic

Daniel Knutson

Erwin Sigel

Roman Furtmuller

Urs Thomet

Frantisek Jursky

Jean-Paul Pierre Potier

Pi-Chuan Fan

Lih-Chu Chiou

Ahmed El Hadri

Rodolphe Razet

Laurin Wimmer

Matheus Meirelles

Marko Mihovilovic

Margot Ernst

Ranjit Verma

Zdravko Varagic

David Chan Bodin Siebert

Christopher Witzigmann

The invention concerns compounds represented by general formula (I) wherein: Z represents a sulfur or oxygen atom; the groups R1 and R2, identical or different, represent each a alkyl group or an alkenyl group; X represents a CO, a CO , an SO, or an SO and the group R represents an alkyl, aryl, alkenyl, or aralkyl group, provided that when Z represents an oxygen atom, X an SO and R a group (a), R1 and R2 do not both represent the methyl group. The invention also concerns methods for preparing said compounds, pharmaceutical compositions containing them and their use as promoter of &ggr;-aminobutyric acid and as medicine particularly designed for treating nervous disorders.

N substituted 3-amino-2,2-di-c-alkyl-1,4-butyrolactones and 1,4-thiobutyrolactones for use as promoter of &ggr;-aminobutyric acid activity and for treating nervous disorders and preparation method

The invention concerns compounds of general formula (I) wherein: Z represents a sulphur or oxygen atom, NH, N-alkyl or Nboc; group R&prime;, identical or different, represent each a hydrogen atom, a OCH group or a OCH O group; group R&Prime; represents a hydrogen or a CH group; group X represents a carbonyl, sulphonyl or CO group; and group R represents an alkyl, aryl, alkenyl or aralkyl group. The invention also concerns the preparation of said compounds, pharmaceutical compositions containing them and their use for stimulating &ggr;-amino-butyric acid activity and as medicine for treating nervous disorders.

N-substituted 1-(lactone) isoquinolones for treating nervous disorders

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Vienna, Austria

Werner Sieghart