United Therapeutics Corporation

Vectura Gmbh

Jüstus-liebig-universität Giessen

Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Medic-aid Limited

Werner Seeger

Thomas Schmehl

Robert Voswinckel

Lewis J Rubin

Horst Olschewski

Robert Roscigno

Carl Sterritt

Tobias Gessler

Andreas Günther

Viktor Magdolen

Thomas Braun

Clemens Ruppert

Aditi Mehta

Timothy E Weaver

Guillermo Barreto

Philipp Markart

Indrabahadur Singh

Marten Szibor

Rajkumar Savai

Marcus Krüger

Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.

Treprostinil administration by inhalation

The present invention relates to novel methods, compositions and kits useful for the treatment of pulmonary diseases such as pulmonary arterial hypertension. In particular, aerosolisable compositions of iloprost are provided which are for use in inhalation therapy. Their administration is by bolus inhalation, which is patient-friendly, effective, and well tolerated. Bolus inhalation may, for example, be achieved using an efficient nebuliser based on the vibrating mesh technology.

Administration of iloprost as aerosol bolus

The present invention relates to a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer, comprising the measurement of the amounts of specific isoforms of GATA6 and/or NKX2-1 in a sample of said subject. Furthermore, the present invention relates to a composition for use in medicine comprising (an) inhibitor(s) of specific isoforms of GATA6 and/or NKX2-1. Additionally, the present invention relates to a kit for use in a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer.

Isoforms of GATA6 and NKX2-1 as markers for diagnosis and therapy of cancer and as targets for anti-cancer therapy

The present invention relates to novel methods, compositions and kits useful for the treatment of pulmonary diseases such as pulmonary arterial hypertension. In particular, aerosolisable compositions of iloprost are provided which are for use in inhalation therapy. The administration is by inhalation over a short period of time, which is patient-friendly, effective, and well tolerated. Inhalation may, for example, be achieved using an efficient nebulizer based on the vibrating mesh technology.

Administration of aerosolised iloprost

The present invention relates to recombinant chimeric proteins comprising a surfactant protein precursor N-terminally fused to a plasminogen activator or comprising a mature surfactant protein N-terminally or C-terminally fused to a plasminogen activator. The invention is also directed to the corresponding nucleic acid molecules encoding such fusion proteins as well as to a method for their production. The invention further refers to a pharmaceutical composition comprising such a fusion protein and to pharmacological uses of an inventive fusion protein for the prevention and/or treatment of inflammatory and interstitial lung diseases.

Chimeric plasminogen activators and their pharmaceutical use

A combination mouthpiece for inhalation therapy devices, having a body ( ) defining an aerosol duct ( ) through which, in use, a stream of air carrying an aerosolized drug is supplied to a patient during inspiration, an inlet hole ( ) through the body for receiving in a releasable and secure manner an oxygen tube adapter ( ), characterised by at least one partition ( ) within the body ( ) defining at least one oxygen duct ( ), the oxygen duct being in a form such that it extends generally parallel with the aerosol duct ( ) and has a flow cross-section sized in order to guide a suitably large oxygen stream from the oxygen tube adapter ( ) through the inlet hole ( ) to the patient.

Combination mouthpiece for inhalation therapy devices used by oxygen dependent patients

Growing community of inventors

Giessen, Germany

Werner Seeger