Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim Pharma Kg

Werner Rall

Guenter Linz

Peter Sieger

Rolf Schmid

Rainer Soyka

Guenther Huchler

Juergen Schnaubelt

Rolf Herter

Uwe Joerg Ries

Gerd Kraemer

Matthias Hoffmann

Gerald Juergen Roth

Frank Hilberg

Thomas Krueger

Joerg Brandenburg

Werner Belzer

Ralf Lock

Zeno A Leuter

Gunnar Schreiner

Uwe Reis

Armin Heckel

Joerg Kley

Waldemar F Pfrengle

Marco Santagostino

Thorsten Lehmann-Lintz

Christian Eickmeier

Markus Ostermeier

Adil Duran

Ulrike Tontsch-Grunt

Jacobus C A Van Meel

Svenja Renner

Stefan Goepper

Carsten Reichel

Christian Kulinna

Joern Merten

Ludwig Gutschera

Michael Konrad

Thomas Bock

Andreas Zopf

Kathrin Pachur

Volkmar Koerner

Waldemar Franz-Augustin Pfrengle

Kathrin Maier

Armin Proell

Heidelore Heimroth

Norbert Birk

Robert Schiffers

Claudia Ochs

Gerald Jürgen Roth

Volkmar Körner

The present invention encompasses a process for preparing compounds of formula (1), wherein a compound of formula (2) is reacted in the presence of a catalyst and a solvent under hydrogen pressure to form a compound of formula (1) and wherein A and R&#x2014;Rare defined herein.

Method of preparing chiral cyclic &#x3b2;-aminocarboxamides

An improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.

Process for preparing amino crotonyl compounds

The present invention relates to a process for preparing betamimetics of formula 1, 

Process for the manufacturing of betamimetics

The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoethanesulfonate, to new manufacturing steps and to new intermediates of this process.

Process for the manufacture of an indolinone derivative

A process for preparing compounds of the formula (I) in which R, R, Rand Rare as defined in the description.

Preparation process

The present invention relates to a process for preparing compounds of general formula I wherein Rand Rare defined as in claim, the pharmaceutically acceptable salts and the solvates thereof, which may be prepared starting from compounds of general formula II wherein Ris defined as in claim

Production method

The invention relates to a novel method for producing scopine esters of the general formula (1), wherein X&#x2014;, R, R1, R2, R3, R4, R3', R4&#x2032;, R6 and R6&#x2032; can have the meanings indicated in the claims and in the description. 

Method for producing scopine esters

Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, processes for preparing them and their use as pharmaceutical compositions.

[object Object]

Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]Amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide: processes for preparing them and their use as pharmaceutical compositions with antiproliferative activity.

Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament

The present invention relates to a process for preparing compounds of general formula I wherein Rand Rare defined as in claimthe pharmaceutically acceptable salts and the solvates thereof, which may be prepared starting from compounds of general formula II wherein Ris defined as in claim

The present invention relates to indolinone derivatives substituted in the 6 position of general formula wherein

Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions

A process for making a compound of formula 1 or a salt thereof, wherein: wherein Ris benzyl, diphenylmethyl, or trityl, each optionally substituted at, if available, an aryl group or an aliphatic carbon atom, with a compound of formula 7 or a salt thereof, to obtain a compound of formula 5, or a salt thereof (b) reducing the nitro group of the compound of formula 5 to an amine group and mesylating this amine group and cleaving the protecting group during the reduction step or after the mesylation step to obtain the compound of formula 1.

Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones

Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compositions.

(R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1(pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition

(R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition

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Mittelbiberach, Germany

Werner Rall