Basf Aktiengesellschaft

Abbott Laboratories Corporation

Abbott Gmbh & Co Kg

Werner Maier

Joerg Rosenberg

Jorg Breitenbach

J&ouml;rg Rosenberg

Helmut Fricke

J&ouml;rg Breitenbach

Stephan Kothrade

Armin Lange

Andreas Kleinke

Thomas Kessler

Sven Grabowski

Ulrich Reinhold

J&uuml;rgen Zeidler

Harald Krull

J&ouml;rg Neumann

Jurgen Zeidler

A process for producing solid dosage forms by a) producing a plastic mixture which comprises at least one active ingredient and at least one polymeric binder, and b) shaping the plastic mixture to the solid dosage forms in a molding calender with two counterrotating molding rolls, wherein one molding roll has at least one annular groove running along its periphery and the other molding roll has at least one ring, running along its periphery, of teeth extending radially outward and able to engage in the annular groove is described.

Method of producing solid dosage forms

The invention relates to a process and an apparatus for producing solid dosage forms by molding plastic active ingredient-containing mixtures with use of a continuously operating molding tool with two parts which cooperate to mold the plastic mixture, with at least one part having a plurality of depressions to receive and mold the plastic mixture, wherein one part has at least two groups, which differ in volume and/or shape, of depressions. Dosage forms which differ in shape or size are obtained in one step.

Method and device for producing different solid dosage forms

Solid, elongate dosage forms ( ) with a long axis ( ) and with a length (L) which is defined by projection of the ends ( ) of the dosage form to the long axis, where a cross-sectional area ( ) oriented perpendicular to the long axis ( ) has an area which is variable along the long axis ( ) and increases from a cross-sectional area ( ) which is located between the ends ( ) and has a minimal area essentially continuously toward the two ends ( ) up to in each case a cross-sectional area ( and respectively) with a maximal area, wherein the distance of the maximal cross-sectional area ( ) which is located near one end ( ) from the maximal cross-sectional area ( ) which is located near the other end ( ) is, projected on the long axis ( ), more than half the length (L) of the dosage form ( ), are described.

Cleavable solid dosage forms and method for the production thereof

A process for producing solid dosage forms, in which (i) a plastic mixture of at least one pharmacologically acceptable polymeric binder with a K value of more than 75, at least one pharmaceutical active ingredient and, where appropriate, conventional pharmaceutical additives is prepared and (ii) the plastic mixture is shaped to the required dosage form, with step (i) being carried out under conditions of temperature and shear energy input such that the reduction in molecular weight of the polymeric binder, expressed as the difference in the K value, is less than 15 is described.

Process for producing solid dosage forms

The invention relates to a process for producing coated solid dosage forms by forming a plastic mixture from at least one thermoplastic physiologically tolerated polymeric binder and at least one active ingredient and extruding the plastic mixture, wherein the extrudate is subsequently treated with at least one liquid or vaporized coating agent, and the coated extrudate is shaped to the required dosage form.

Process for producing coated solid dosage forms

Production of lenticular tablets by melt calendering

Process and apparatus for the production of divisible tablets

A process for producing solid combination tablets which have at least two phases comprises molding a melt of a polymeric binder with or without at least one active ingredient, there being at least one solid product, which may contain an active ingredient incorporated into the still plastic composition during the molding step.

Process for producing solid drug forms having at least two phases

Production of covered tablets

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Schifferstadt, Germany

Werner Maier