Other

Siemens Healthcare Diagnostics Gmbh

Bayer Aktiengesellschaft

Miles Inc.

Werner Kroll

Mathias Gehrmann

Andreas Knorr

Guido Hennig

Detlef Schuppan

Elmar-Reinhold Burchardt

Rudolf Schohe-Loop

Bernhard Schulte

Karlheinz Hildenbrand

Klaus Wehling

Claus Burkhardt

James W Stave

Alexander Riebel

Christoph Petry

Horst Weber

Bernd Sennhenn

George B Teaney, Iii

Maria-Luisa Rodriguez

Robert P Thiel

Philip R Strom-Jensen

William Rosenberg

Michael Volker

Elmar Reinhold Burchardt

Michael Becka

Werner Schröder

Sylvia Unger

Michael J Arthur

Thomas Doege

Alastair D Burt

Massimo Pinzani

Ferdinand Rombout

The invention provides diagnostic methods, kits, and systems, and related computer-readable media, which use multiple blood marker values, including serum and plasma marker values, to aid in the diagnosis of the status or progress of a liver disease in a patient. The invention also provides methods and systems, and related computer-readable media, that use blood marker values, including serum and plasma marker values: (1) to screen for active ingredients useful in the treatment of a liver disease; (2) to aid in the selection of treatment regimens for patients that are predisposed to, or suffer from, liver disease; and (3) to aid in the design of clinical programs useful in monitoring the status or progress of liver disease in one or more patients.

Liver disease-related methods and systems

The present invention relates to monoclonal antibodies binding to the N-terminal procollagen (III) propeptide (PIIINP) molecule which is a proteolytic fragment emanating from the specific cleavage of procollagen (III) by N-proteinase after exocytosis and to an assay using these antibodies.

Monoclonal antibody and assay for detecting PIIINP

The present invention concerns a method for diagnosing liver fibrosis wherein two or more diagnostic markers are measured and the measurements are correlated by a mathematic algorithm characterized in that the diagnostic markers are selected from the group N-terminal procollagen III propeptide (PIIINP), Collagen IV, Collagen VI, Tenascin, Laminin, Hyaluronan, MMP-2, TIMP-1 and MMP-9/TIMP-1 complex. The algorithm can be used to predict the histological score of a liver biopsy.

Assessment of liver fibrosis scoring with serum marker algorithms

An assay device for the detection of analyte in a sample, methods and immunoassay formats for performing an assay with or without the device, and methods for manufacturing the device are provided. The device is a continuous liquid flow channel having a proximal and a distal end, with a detection membrane in fluid communication with the distal end of the flow channel. Interspersed between the assay buffer and detection membrane, and continuous with the liquid flow channel, are a sample delivery means, one or more reservoirs containing the reagents necessary for conducting the assay, and, optionally, mixing or incubation reservoirs for combining the sample and reagents. The geometry of the liquid flow channel regulates the flow rate of the liquids through the channel, thereby controlling incubation, mixing and reaction time. The preferred detection membrane is an immunochromatographic test strip containing immobilized reagents. The detection of labeled reagent in a particular area of the detection membrane reflects the presence or relative amount of analyte in the sample. Detection may be achieved visually. One or more liquid flow channels may be contained within a single housing for simultaneous, consecutive, or comparative sample analysis.

Integrated assay device and methods of production and use

The invention relates to a kit comprising a pharmaceutical composition containing repinotan or a physiologically acceptable salt of repinotan, and a means for the determination of the concentration of repinotan or its metabolites in body fluids, and also new pharmaceutical compositions containing repinotan or a physiologically acceptable salt of repinotan, and processes for their preparation.

Repinotan kit

The present invention is directed to the use of polymer blend films consisting of polycarbonate and polyalkylene terephthalate supports for diagnostic test strips.

Use of polymer blend films as supports for diagnostic test strips

Growing community of inventors

Solingen, Germany

Werner Kroll