Sanofi-a Ventis Deutschland Gmbh

Hoechst Aktiengesellschaft

Aventis Pharma Deutschland, Gmbh

Hoechst Marion Roussel Deutschland Gmbh

Werner Kramer

Heiner Glombik

Wendelin Frick

Hubert Heuer

Hans-Ludwig Schaefer

Gerhard Jaehne

Stefanie Flohr

Andreas Lindenschmidt

Gunther Wess

Alfons Enhsen

Reinhard Kirsch

Stefan Theis

Oliver Plettenburg

Hans-Ludwig Sch&auml;fer

Harm Brummerhop

Eugen Falk

Stefan Mullner

Hans-Ludwig Schäfer

Eric Galia

Siegfried Stengelin

Andreas Gerhard Weichert

Jan-Robert Schwark

Hans Jochen Lang

Karl-Heinz Baringhaus

Matthias Kroggel

Hans-Willi Jansen

Matthias Gutweiler

Horst Neubauer

G Unther Wess

Eugene Falk

Alfons Ehnsen

Klaus Bock

Harm Brummerhof

This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives with improved properties, method for producing the same, drugs containing said compounds and use thereof.

1,4-benzothiepin-1, 1-dioxide derivatives with improved properties method for producing the same, drugs containing said compounds and the use thereof

This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with fluorine, method for producing the same, drugs containing said compounds and use thereof.

1,4-benzothiepin-1,1-dioxide derivatives which are substituted with fluorine, method for producing the same, drugs containing said compounds and use thereof

This invention relates to Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof.

1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof

This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with cyclohexyl groups, method for producing the same, drugs containing said compounds and use thereof.

1,4-benzothiepin-1,1-dioxide derivatives which are substituted with cyclohexyl groups, method for producing the same, drugs containing said compounds and use thereof

The invention describes a method for isolating an intestinal protein which is able to bind cholesterol and/or cholesterol uptake inhibitors.

Method for isolating an intestinal cholesterol binding protein

The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.

Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use

Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.

Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use

One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.

Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use

Novel thiophene glycoside derivatives of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.

Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof

One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.

Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use

The invention describes a method for isolating an intestinal protein which is able to bind cholesterol and/or cholesterol uptake inhibitors. Methods of identifying inhibitors of cholesterol uptake and related pharmaceuticals and methods of treatment also are described.

One embodiment of the invention relates to compounds of the formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.

Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use

Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof. The invention relates to substituted aromatic fluoroglycoside derivatives of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and process for their preparation. The compounds are suitable for example as antidiabetics.

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Mainz-Laubenheim, Germany

Werner Kramer