Ciba Specialty Chemicals Corporation

Werner H&ouml;lzl

Marcel Schnyder

Wolfgang Haap

Dietmar Ochs

Karin Puchtler

Dieter Reinehr

Rudolf Zink

Armando Di Teodoro

Arakali Srinivasarao Radhakrishna

Surendra Umesh Kulkarni

Asawari Bhikaji Mahtre

Sitaram Pal

Rainer Hans Traber

Urs Burckhardt

Hanspeter Sauter

Karin Petzold

Dinesh Narendra Rele

J&uuml;rgen Koppold

R&uuml;diger Hirsch

Dinesh Narenda Rele

Uwe Gronde

Marc I Schnyder

Hydroxystilbene compounds used as microbicidal active substances

The present invention relates to the use of 4-hydroxyisothiazole compounds as antimicrobially active substances, certain new 4-hydroxyisothiazole compounds and a process for their preparation.

4-Hydroxyisothiazole compounds

4-aminobut-2-ynecarboxylic acid derivatives

There is described a process for the preparation of halogenated hydroxydiphenyl compounds of formula (1) by acylation of a halogenated benzene compound (first stage), etherification of the acylated compound with a halogenated phenol compound, which is not further substituted in the ortho-position (second stage), oxidation of the etherified compound (third stage) and hydrolysis of the oxidized compound in a fourth stage, wherein the reaction of the second stage is carried out in the presence of K CO and any desired copper catalyst, where K CO is used in a concentration of from 0.5 to 30 mol, based on the phenol compound employed of formula (6), according to the reaction scheme (I) in which R and R independently of one another are F, Cl or Br; R and R independently of one another are hydrogen; or C -C alkyl; m is 1 to 3; and n is 1 or 2. The compounds of formula (1) are used for protecting organic materials and articles from microorganisms.

Process for the preparation of halogenated hydroxydiphenyl compounds

Microbicidal active substances

Hydroxyphenylvinylthiazoles

A description is given of a three-step process for the preparation of 4,4&prime;-dihalogen-o-hydroxydiphenyl compounds of formula (1) which comprises: a) hologenating an alkoxyphenol of formula (6) (&equals;a ), reacting the resulting halogenated phenol compound of formula (5) with p-dihalobenzene of formula (4 ) in the presence of copper and/or copper salts to the diphenyl ether compound of formula (2) (&equals;a ) and subsequent ether fission to the diphenyl ether compound of formula (1) (&equals;a ); or b) reacting an alkoxyphenol of formula (6) with the halophenol of formula (4 ) to the compound of formula (3) (&equals;b ), then halogenating this compound (&equals;b ) and subsequent ether fission of the resulting compound of formula (2) to the diphenyl ether compound of formula (1) (&equals;b ). The compounds of formula (1) are used for protecting organic materials and objects against microorganisms.

Process for the preparation of 4,4&prime;-dihalogen-o-hydroxydiphenyl compounds

4-hydroxyisothiazole compounds

A detergent additive is described, which comprises at least one swellable layered silicate, an antimicrobial active substance and a surfactant and, optionally, an alkali salt. This detergent additive is distinguished in that it protects the antimicrobial active substance from oxidation by the bleaches which are usually present in detergents and in that said active substance is only released during the washing process.

Agglomerated antimicrobial detergent additive comprising swellable layered silicate and surfactant

Microbicidal active ingredients

A process for the preparation of halohydroxydiphenyl compounds useful for protecting organic materials and articles from microorganisms, of the formula

Growing community of inventors

Eschentzwiller, France

Werner Hölzl

Growing community of inventors

Eschentzwiller, France

Werner H&ouml;lzl

Werner Hölzl