Hoechst Aktiengesellschaft

Werner Fulberth

Willi Stammberger

Alfred Sickmuller

Roman Muschaweck

Dietrich Hiller

Richard Leeb

Irmgard Hoffmann

Gerhard Ross

Manfred Radau

Karl Schmitt

Alfred Muller

Stabilized medicinal substances, a process for the preparation thereof, and stable medicinal formulations Stabilized compounds of the formula I ##STR1## in which R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the stated meanings, and a process for the preparation thereof, are described. The stabilized compounds are suitable for the manufacture of medicinal formulations. The formula I compounds are stabilized by a polymeric protective coating before being compressed in tablet form.

Stabilized polymer film coated compounds and stabilized formulations in

Salts formed between penbutolol and furosemide or piretanide, pharmaceutical compositions containing such salts, and methods for treating diseases of the coronary and circulatory systems with such salts.

Binary compositions of penbutolol and furosemide or piretanide

Composition containing acesulfam or a salt thereof, a soluble, CO.sub.2 -yielding compound, optionally a physiologically acceptable acid as auxiliary, and gelatin powder as dry binder, and its use for the manufacture of tablets.

Acesulfam-containing composition tablets on the basis thereof and

What is disclosed are medicinal compositions, useful as anti-depressive agents, containing a compound of the formula; ##STR1## in which R.sub.1, R.sub.3 and R.sub.4, which may be identical or different, and represent hydrogen atoms or lower alkyl or aralkyl groups, and R.sub.2 and R.sub.2 ', which may be identical or different, represent hydrogen or halogen atoms, hydroxy or trifluoromethyl groups or lower alkyl, alkoxy or aralkoxy groups, it also being possible that two adjacent radicals form an alkylene-dioxy radical, and R.sub.5 represents a hydrogen or halogen atom, a hydroxy, trifluoromethyl or nitro group or a lower alkyl, alkoxy or aralkoxy radical, and their salts with acids (active substance A) together with 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4 (3H,5H)-dione (active substance B), and their use as antidepressive agent.

Medicinal composition and its use as antidepressive agent

High-dosage, orally administrable antibiotic preparations containing an antibiotic agent of the cephalosporin type and 5 to 15 % of a mixture of auxiliary agents, and process for preparing them.

Growing community of inventors

Kelkheim, Germany

Werner Fulberth