Bruker Biospin Gmbh

Broker Biospin Gmbh

Bruker Biospin Ag

Werner E Maas

Eckhard Bez

Yit Aun Lim

Michael Fey

Kimberly Colson

Don Piroli

Brian Marquez

Robert Krull

Martin Hofmann

Oskar Schett

Daniel Guy Baumann

Jonathan De Vries

Joost A B Lohman

Sami Antoine Adrien Jannin

Xiaozhong Zhang

Martin Rindlisbacher

Joost AB Lohman

A monitoring cell, used to perform a measurement in an NMR spectrometer of a reaction fluid produced by a reaction vessel, has a body having inlet and outlet transport coaxial capillaries for transporting the reaction fluid between the body and the reaction vessel. Cooling lines are also positioned coaxially with the transport capillaries to transport cooling liquid between the body and the reaction vessel. The cell further has a hollow sample probe for insertion into the NMR spectrometer and a coupler section that removably connects the sample probe to the body so that the inlet transport capillary extends through the body into the interior of the sample probe and the outlet transport capillary is sealed to the sample probe to allow reaction fluid that enters the sample probe via the inlet transport capillary to exit the sample probe via the outlet transport capillary.

NMR reaction monitoring flow cell

A method and apparatus for producing a hyperpolarized sample material for use in an NMR investigation provides for a cryogenic region having a target material containing a first hyperpolarizable nuclear species, a second hyperpolarizable nuclear species, and a nuclear spin polarizing agent, wherein the first nuclear species has a higher magnetic moment than the second nuclear species. Microwave energy is used to excite electron spin transitions in the polarizing agent in the presence of a magnetic field. The first hyperpolarizable nuclear species is thereby caused to interact with the electron spin system in the polarizing agent and generate hyperpolarization of at least the first nuclear species of the target material. The target material is then subjected to a lowered magnetic field, wherein the lowered magnetic field facilitates polarization transfer by nuclear thermal mixing between the species to thereby hyperpolarize the second nuclear species.

Device and method for rapid dynamic nuclear polarization

A transport device for conveying an object to be transported () between an input point (A) and a supply point (Z), where the object to be transported () can be supplied to an RT tube () of a cryostat (), wherein the input point (A) is both horizontally and also vertically spaced apart from the supply point (Z), wherein a transport tube () is provided for pneumatically conveying the object to be transported within the transport tube () from a first transfer point (B) to a second transfer point (C), is characterized in that the transport tube () is vertically arranged, a first transport container (TB) and a second transport container (TB) are provided for receiving the object to be transported (), a first transfer device is disposed between the input point (A) and the first transfer point (B), and a second transfer device is provided between the second transfer point (C) and the supply point (Z).

Automated transport device for NMR measuring samples, cryo-magnetic system with automated transport device, transport container for an automated transport device and method for conveying an NMR measuring sample

A method for spectrometric investigation of a plurality of samples dissolved in a solvent comprises: (a) guiding a first solvent with a sample through an SPE cartridge for concentrating the sample in the cartridge; (b) positioning the cartridge in a carrier for a plurality of cartridges; (c) repeating steps (a) and (b) for a desired number of samples; (d) drying the concentrated samples through removal of the residual first solvent, in particular, dehydration or evaporation; (e) dissolving each sample in a second solvent, transferring these dissolved samples from the cartridges to a spectrometer and acquiring a spectrum of each sample. All samples are dried together in step (d) subsequent to steps (b) and (c) while the cartridges with samples are positioned in the carrier. The drying process is thereby considerably accelerated in a straightforward technical manner.

Drying SPE cartridges

In a nuclear magnetic resonance probe, the sample coil is connected to the RF excitation source via transmission lines that are arranged to generate one or more nodal points at theH excitation frequency along their lengths and a balanced magnetic filed profile within the sample coil. Heat exchangers are then connected directly to the inner conductor of the transmission line at these nodal points. The transmission line inner conductors are in direct contact with the sample coil and efficiently cool the coil to cryogenic temperatures without interfering with theH resonance or RF profile.

Nuclear magnetic resonance probe with cooled sample coil

A nuclear magnetic resonance (NMR) probe circuit is used with a sample coil tuned to a primary frequency f. The circuit is arranged to have a plurality of points of electric field minima at the ffrequency. One or more additional frequencies may be coupled to the circuit at these points, without interaction with f. The probe circuit also uses an impedance coupled between two of the minima points that affects the frequency response at the additional frequency or frequencies, without affecting the frequency response at f. The impedance may be made adjustable to allow tuning of the relative frequency resonances.

NMR probe circuit with nodal impedance bridge

A flow-through sample container, or flow cell, according to the present invention resides with the channel of magnetic resonance probe without being fixed thereto. The flow cell is removable from the spectrometer while leaving the probe in place, allowing easy cleaning of the probe channel and replacement of the flow cell. An insertion tool that houses the flow cell may be used to safely introduce it to the probe. Input and output capillaries serve as fluid pathways for fluid samples entering and leaving the flow cell, respectively. These capillaries may be connected to the flow cell with a manually operable connector, allowing easy disconnection of the flow cell from the input and output conduit. The capillaries enter through different ends of the spectrometer bore, so that the fluid samples flow enter one end of the spectrometer and exit through the other.

NMR spectrometer with flowthrough sample container

A circuit for a nuclear magnetic resonance probe uses three resonators to create resonances intermediate to the resonator resonant frequencies. The circuit is particularly useful for creating magnetic fields for two closely spaced high frequencies, such as those used for the excitation ofH andF. The resonators are arranged in a parallel combination, or the electrical equivalent thereof, with input ports connected to it for inputting the desired high frequency resonances. Admittance inverters may be used to provide isolation between the input ports. Some of the resonators and the admittance inverters may be transmission lines. The transmission lines may have additional ports for additional input signals of lower frequencies located at null points for the frequencies of the signals coupled to the primary input ports. Adjustable dielectric components in the resonator transmission lines may be used for tuning purposes.

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Boxford, MA, United States of America

Werner E Maas