Dsm IP Assets B.v.

Universitat Basel

Werner Bonrath

Thomas Netscher

Jonathan Alan Medlock

Raphael Beumer

Matthias Beller

Andreas Hendrikus Maria De Vries

Johannes Tschumi

Ulla Letinois

Bettina Wuestenberg

Gerardus Karel Maria Verzijl

René Tobias Stemmler

Jan Schütz

Marc-André Mueller

Jan Schuetz

Michael Schneider

Bettina Wüstenberg

Roman Goy

Rolf Kuenzi

Marcel Joray

Igor Iouranov

Lioubov Kiwi-Minsker

Viktor Zimmermann

Axel Buss

Thomas Clavey

Richard Van Heck

Thomas Mueller

Andrea Mattevi

Hongyan Shen

Francesco Mascarello

Albert Renken

Johannes Gerardus De Vries

Silke Dorn

Yuting Fan

Nicholas Turner

Pim Puylaert

Claude Stritt

Theodor Zweifel

Hajo Lehmann

Fenrando Cardenas Lizana

Anne Laure Dessimoz

Jan-Marc Delpho

Domenico Soriano

Estel Canet-martinez

Asad Saib

Ulrich Hintermair

Fabrice Aquino

Jose Ruben Casstellanos

Martin Schürmann

Yann Pressel

Michele Tavanti

Fabio Parmeggiani

Christof Sparr

Alex Gaa

Lioubov Kiwi Minsker

Bettina WÜSTENBERG

Michael Thomann

Peter Wasserscheid

Ingolf Gummin

De Andreas Hendrikus Maria Vries

Sandra HÜBNER

Jan SCHÜTZ

Peter Schulz

Andreas Hendrikus Maria Vries De

Angela Wildermann

Reinhard Karge

Jocelyn Fischesser

Wolfgang Hölderich

Bernhard Markus Ernst Russbüldt

Verena Ritzerfeld

Erhard Henning Fleischhauer

Peter Hans Riebel

Felix Imberi

Giancarlo Cravotto

Emily Boretto

Zihilin Wu

Thomas Buchholz

Joël Wellauer

Dragan Miladinov

Laurent Lefort

Christina Smuda

The present invention relates to a process for producing specific α,β-unsaturated carboxylates.

Process to produce specific alpha,beta-unsaturated carboxylates

The present invention is directed to a process for the manufacture of 1,1,4,4-tetramethoxy-2-butene from 2,5-dimethoxy-2,5-dihydrofuran with methanol in the presence of an acidic ion exchanger as catalyst, whereby the molar ratio of 2,5-dimethoxy-2,5-dihydrofuran to methanol is ≥1:45. The present invention is further directed to a process of separating 1,1,4,4-tetramethoxy-2-butene, methanol and 2,5-dimethoxy-2,5-dihydrofuran from each other and H2O whereby a basic compound, preferably a basic metal salt or a basic ion exchanger, is present. Both processes can be carried out on an industrial scale, batch-wise or in continuous mode and are sustainable since the selectivity and the space-time-yields are high and less waste compared to known processes is produced. Further objects of the present invention are the use of a basic compound in the distillation of a mixture comprising H2O, 1,1,4,4-tetramethoxy-2-butene and 2,5-dimethoxy-2,5-dihydrofuran, as well as the use of an acidic ion exchanger as catalyst in a reaction of 2,5-dimethoxy-2,5-dihydrofuran with methanol to 1,1,4,4-tetramethoxy-2-butene, whereby the molar ratio of 2,5-dimethoxy-2,5-dihydrofuran to methanol is ≥1:45.

Sustainable process for the manufacture of 1,1,4,4-tetramethoxy-2-butene

The present invention relates to a new process for the production of new specific intermediates, which are preferably used in the production of vitamin A, vitamin A acetate, or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin.

Process for production of new sulfolenic intermediates

The present invention relates to a new process for the production of vitamin A and/or its derivatives.

Process for production of vitamin A

The present invention relates to a new compound and the dehydrogenation of that compound to produce retinal.

Dehydrogenation process

The present invention relates to a new process for the production of retinal or hydrogenated form of retinal.

Process for the production of retinal

The present invention relates to a new process of production of menaquinone 4, which is also known as vitamin K2.

Vitamin K2 synthesis

The present invention relates to novel process for the production of ketoisophorone via biocatalytic conversion of isophorone, in particular a one-pot biocatalytic system for conversion of α-isophorone in a two-step oxidation process, with a first oxidation being catalyzed by a heme containing oxidoreductase such as a cytochrome P450 monooxygenase followed by another oxidation which can be either a chemical reaction or a biocatalytic reaction, in particular wherein the oxidation is catalyzed by an NAD(P) or NADP(H)-dependent oxidoreductase. The invention further provides polypeptides and nucleic acid sequences coding for cytochrome P450 monooxygenase with modified (higher) substrate selectivity, total turnover numbers and/or (re)activity compared to the wild-type enzyme. Ketoisophorone is useful as building block in the synthesis of vitamins and carotenoids.

Regioselective hydroxylation of isophorone

The application relates to a process for the preparation of a compound of formula (II) by cyclisation of a polyene of formula (I), and to an intermediate of formula (III). The obtained compounds are useful intermediates in the preparation of specific isoprenoids, preferably in the production of vitamin A and derivatives of vitamin A.

Process for the preparation of intermediates for the synthesis of vitamin A derivatives from polyenes by cyclisation

Growing community of inventors

Kaiseraugst, Switzerland

Werner Bonrath