Kali-chemie Pharma Gmbh

Werner Benson

Horst Zeugner

Michael Ruhland

Hans Liepmann

Henning Heinemann

Klaus-Ullrich Wolf

Ineke Van Wijngaarden

Herbert Muesch

Uwe Schoen

Ulf Preuschoff

Wolfgang Kehrbach

Andreas Fuchs

Harald Waldeck

Karin Van Charldorp

Peter C Gregory

Ton Hulkenberg

Peter-Colin Gregory

Martin Tulp

Derk Hamminga

Pharmacologically active compounds corresponding to the general formula I ##STR1## in which R.sup.1 represents hydrogen, a lower alkyl or cycloalkyl-alkyl group or an optionally substituted phenyl-lower alkyl group,

6-oxoazepinoindole compounds, and pharmaceutical compositions containing

Compounds corresponding to the formula I ##STR1## in which R.sup.1 represents hydrogen, lower alkyl or cycloalkylalkyl with 4-7 carbon atoms,

1,7-fused 1H-indole-2-carboxylic acid-N-(1,4-benzodiazepin-3-yl)amides

Tetraoxo compounds of the Formula (I) ##STR1## wherein R.sup.1 is an alkyl, alkenyl, phenylalkyl or cycloalkylalkyl group,

Tetraoxo compounds and pharmaceutical compositions

[1,2]-fused 1,4-benzodiazepine compounds are disclosed corresponding to the general formula I ##STR1## wherein X is an oxygen or sulfur atom or an optionally substituted imino group, R.sub.1 is a hydrogen or halogen atom, lower alkyl radical, a lower alkoxy radical or a nitro group and R.sub.2 is a hydrogen or halogen atom, a lower alkyl radical, a lower alkoxy radical or a nitro group, or if R.sub.1 is a hydrogen atom, R.sub.2 may also be a lower alkylthio radical, or, if R.sub.1 is a hydrogen atom and X is a sulfur atom or an imino group, R.sub.2 may be a trifluoromethyl radical; or R.sub.1 and R.sub.2 are bonded to adjacent carbon atoms and together denote a methylenedioxy or ethylenedioxy radical; R.sub.3 is an optionally substituted furyl, thienyl, pyrrolyl or pyridyl radical and n is zero or, if R.sub.3 is furyl or thienyl, n may be 0 or 1. The compounds may be in the form of their optical isomers or acid addition salts. The compounds exhibit neuroleptic properties. Processes for preparing the compounds and pharmaceutical compositions containing them are also disclosed.

Isomeric 2-chloromethyl-1,4-benzodiazepine or

[1,2]-Fused 1,4-benzodiazepine compounds, process for their preparation

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Seelze, Germany

Werner Benson