Dong-A St Co., Ltd.

Dong-A Pharm. Co., Ltd.

Dong-A Pharmaceuticals Co. Ltd.

Weon Bin Im

Tae Ho Lee

Jae Keol Rhee

Chong Hwan Cho

Sung Hak Choi

The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such asand, anaerobic microorganisms such asand Clostridia, and acid-resistant microorganisms such asand. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

Oxazolidinone derivatives

The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as, Staphylococci, Enterococci and Streptococci anaerobic microorganisms such asand Clostridia, and acid-resistant microorganisms such asand. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such asand Clostridia, and acid-resistant microorganisms such asand. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

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Yongin-si, South Korea

Weon Bin Im