Astrazeneca Ab

Dizal (jiangsu) Pharmaceutical Co., Ltd.

Dizal Pharmaceutical Co., Limited

Wenzhan Yang

Dedong Wu

Daniel T Robbins

Michelle Lamb

Alexander Hird

Jeffrey Wallace Johannes

Bo Peng

Steven Kazmirski

Xiaolan Zheng

Matthew Belmonte

Paul Secrist

Jason Grant Kettle

Claudio Edmundo Chuaqui

Sameer Pralhad Kawatkar

Qibin Su

Qing Ye

Neil Patrick Grimster

Richard Donald Woessner

Jon James Winter-Holt

John Paul Secrist

Magnus K Nilsson

Annika Birgitta Margareta Astrand

James Mccabe

Tudor Grecu

Daniel William Robbins

Matthew Alan Belmonte

Michelle Laurae Lamb

Steven Lee Kazmirski

Melissa Marie Vasbinder

Linette Lys Ruston

Annika Birgitta Margareta ÅStrand

Jeffrey Johannes

Sameer Kawatkar

Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein

Compounds and methods for inhibiting JAK

Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.10000]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I) and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.10000]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.

Mcl-1 inhibitors and methods of use thereof

Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.10,000]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I) and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.10000]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.

MCL-1 inhibitors and methods of use thereof

Growing community of inventors

Waltham, MA, United States of America

Wenzhan Yang