Cytokinetics, Inc.

Symyx Technologies, Inc.

Wenyue Wang

Bradley Paul Morgan

Pu-Ping Lu

Hong Jiang

David John Morgans, Jr

Xiangping Qian

Bing Yao

Chihyuan (Grace) Chuang

Qing (Kevin) Lu

Dominique Charmot

Chihyuan Chuang

Luke W Ashcraft

Han Ting Chang

Scott E Collibee

Susumu Yamaki

Kazuyuki Tsuchiya

Mark Vanderwal

Takuya Makino

Ikumi Kuriwaki

Toshio Kurosaki

Ryuichi Sekioka

Eriko Honjo

Yuka Koizumi

Naoto Katoh

Chris Evans

Makoto Yamasaki

Marcelo Eduardo Piotti

Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X, X, R, R, R, R, R, and Rare as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Bicyclic 1,4-diazepanones and therapeutic uses thereof

Provided herein are compounds of formula (1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X, X, R, R, R, R, R, and Rare as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R, R, R, G, G, and Gare as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Cardiac sarcomere inhibitors

Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.

Certain chemical entities, compositions, and methods

A method of free radical polymerization and for cleaving a thio group from the resulting polymer is provided. The method comprises forming a mixture of one or more monomers, at least one free radical source and a control agent, wherein the control agent comprises a thio moiety. The mixture is polymerized, and the resulting polymer is mixed with a free radical source, and optionally an addition fragmentation agent under cleavage conditions. The thio moiety on the polymer is replaced with a group of interest.

Cleaving and replacing thio control agent moieties from polymers made by living-type free radical polymerization

Control agents that have a nitrogen-nitrogen bond covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization of a wide variety of monomers. These control agents provide superior properties for control of the polymerization and/or the properties of the polymers obtained and/or the monomers that may be polymerized. In some embodiments, a bulky group is pendant off the activated thiocarbonyl portion of the control agents. Multifunctional control agents provide the opportunity for a variety of structurally unique polymers, including block copolymers, stars and hyper-branched polymers.

Control agents for living-type free radical polymerization, methods of polymerizing and polymers with same

Growing community of inventors

Sunnyvale, CA, United States of America

Wenyue Wang