Uwm Research Foundation, Inc.

Marquette University

Wisconsin Alumni Research Foundation

University of Wisconsin-milwaukee Research Foundation

Wenyuan Yin

James M Cook

David A Baker

Edward Merle Johnson, Ii

Ranjit Singh Verma

Michael L Van Linn

Edward Merle Johnson

Edward Merle Ii Johnson

The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.

Cysteine and cystine bioisosteres to treat schizophrenia and reduce drug cravings

The present invention discloses cysteine prodrugs having the general formula: cystine dimers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimers of the protected cysteine analogs having the general formula:  The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimers, and analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.

Cysteine and cystine prodrugs to treat schizophrenia and reduce drug cravings

The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.

Cysteine prodrugs to treat schizophrenia and drug addiction

Provided are compounds having the general structure according to Formula (I): Further provided are pharmaceutical compositions comprising these compounds. The invention still further provides methods of treating alcoholism, methods of reducing alcohol intake, methods of treating anhedonia, and methods of treating anxiety using theses compounds or the compositions containing them.

Aza-beta-carbolines and methods of using same

The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction. Exemplary prodrugs include the cysteine compound having the formula as well as cystine dimers thereof.

Growing community of inventors

Milwaukee, WI, United States of America

Wenyuan Yin