Remegen, Ltd.

Remegen Co., Ltd.

Wenting Luo

Jianmin Fang

Changjiang Huang

Hui Ye

Jing Jiang

Qiaoyu Xu

Nan Shen

Xiuzhi Zhan

Qiaohua Hou

Shenjun Li

Mingxue Wang

Hu Chen

The present invention provides a linker for preparing antibody-drug conjugates and antibody-drug conjugates prepared by the linker, as well as use of the antibody-drug conjugates in a medicament for treating tumor. The linker is capable of coupling simultaneously with the thiol group or amino group on the antibody or functional fragment of the antibody, especially it is capable of coupling with 2, 3 or 4 thiol groups on the antibody or functional fragment of the antibody. A coupled product is uniform and structurally stable.

Linker for antibody-drug conjugates and its use

The present invention discloses an antibody drug conjugate that targets MSLN. The present invention also disclosed a method of making the antibody drug conjugate (ADC). The present invention further discloses a novel MSLN antibody or a functional fragment thereof comprising engineered heavy and light chains.

Anti-mesothelin antibody and antibody drug conjugate thereof

Growing community of inventors

Yantai, China

Wenting Luo