Irm LLC

Novartis Ag

Wenshuo Lu

Thomas H Marsilje, Iii

Bei Chen

Xiaohui He

Songchun Jiang

Yun He

Kunyong Yang

Christian Cho-Hua Lee

Thomas Marsilje

Nathanael Schiander Gray

Tao Jiang

Shifeng Pan

Pierre-Yves Michellys

Badry Bursulaya

Phillip B Alper

Daniel Mutnick

Arnab Kumar Chatterjee

Yun Long

Tetsuo Uno

Yongping Xie

Yuan Mi

Robert Epple

Wenqi Gao

Yunho Jin

Wei Pei

Yahua Liu

Gerald Lelais

Matthew McNeill

Michael Roberts

Matthew H McNeill

Matthew H Mcneill

Phillip Alper

Iii Thomas H Marsilje

Michael J Roberts

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating EGFR activity, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated EGFR activity.

Compounds and compositions for modulating EGFR Activity

The invention provides novel pyrimidine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-1R) or analplastic lymphoma kinase (ALK).

Compounds and compositions as kinase inhibitors

The invention provides novel pyrimidine derivatives of formula I and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-IR) or analplastic lymphoma kinase (ALK). 

Pyrimidine derivatives as kinase inhibitors

The invention provides novel pyrimidine derivatives of formula (I) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-IR) or analplastic lymphoma kinase (ALK). 

The invention provides novel pyrimidine derivatives of formula (1) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-1R) or anaplastic lymphoma kinase (ALK). 

2-biphenylamino-4-aminopyrimidine derivatives as kinase inhibitors

The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.

Compounds and compositions as protein kinase inhibitors

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia. 

Heterotetracyclic compounds as TPO mimetics

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.

Compounds and compositions as TPO mimetics

The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.

Immunosuppressant compounds and compositions

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San Diego, CA, United States of America

Wenshuo Lu