Chongqing Pharmaceutical Research Institute Co., Ltd

Wenrun Ye

Jie Deng

Jie Luo

Bo Lin

Yongmei Qin

Meng Lin

Bin Fan

Zhengyong Zhu

Junlai Luo

Huafu Sun

Chunyan Dan

A method of purifying a salt of pemetrexed having a structure of formula (III) by salting-out, wherein if Mis H, then each of Mand Mis independently H, Li, Naor K, provided that both of them are not H; if Mis Li, Naor K, then each of Mand Mis independently Li, Naor K. 

Method of purifying a salt, sodium salt and disodium salt of pemetrexed

The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.

Morphinan derivatives and preparation methods thereof

Three new crystalline forms of pemetrexed diacid, preparation methods and uses thereof are disclosed. These preparation processes are simple and have better practicality.

Crystalline forms of Pemetrexed diacid, and preparations thereof

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Chongqing, China

Wenrun Ye